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Porphyrias, Hepatic

Known as: Hepatic Porphyrias, Hepatic Porphyria, Porphyrias, Hepatic [Disease/Finding] 
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by… 
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (6)

Acute intermittent porphyriaCafe-au-lait macules with pulmonary stenosisCoproporphyriaPorphobilinogen synthase deficiency

Broader (2)

Disorders of Porphyrin MetabolismLiver diseases
In BloodMicrobiologicalchemically inducednursing therapy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Modulation of penetrance by the wild-type allele in dominantly inherited erythropoietic protoporphyria and acute hepatic porphyrias
We have recently demonstrated that in an autosomal dominant porphyria, erythropoietic protoporphyria (EPP), the coinheritance of… 
1989
1989
The relation between the oxidative biotransformation of hexachlorobenzene and its porphyrinogenic activity.
Highly Cited
1987
Highly Cited
1987
Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism.
Review
1986
Review
1986
Control of 5-aminolevulinate synthase in animals.
1982
1982
Induction of porphyria in the rat by chronic versus acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Highly Cited
1981
Highly Cited
1981
Safety of anticonvulsants in hepatic porphyrias
Because acute attacks of porphyria may be precipitated by anticonvulsants, a therapeutic dilemma arises when seizures complicate… 
1981
1981
Effects of dietary antioxidants on the biotransformation and porphyrinogenic action of hexachlorobenzene in two strains of rats.
Highly Cited
1980
Highly Cited
1980
Acute ethanol ingestion and haem biosnthesis in health subjects
Abstract. The effects of acute ethanol ingestion on the activities of the enzmes of haem biosnthesis in peripheral blood cells… 
1979
1979
A comparison of a commercial polybrominated biphenyl mixture, 2,4,5,2',4',5'-hexabromobiphenyl and 2,3,6,7-tetrabromonaphthalene as inducers of liver microsomal drug-metabolizing enzymes.
1976
1976
Studies in porphyria; v. Drug oxidation rates in hereditary hepatic porphyria
The mean plasma half‐life (T½) of antipyrine was prolonged (21.69 ± 1.92 hr) in a group of 10 patients with hereditary hepatic… 
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