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Poly [ADP-Rbose] Polymerase 1 p85

Known as: ADPRT 1 p85, Poly(ADP Ribose) Polymerase p85, PARP1 p85 
Poly [ADP-ribose] polymerase 1 p85 (800 aa, ~89 kDa) is encoded by the human PARP1 gene. This protein is released from the full length poly [ADP… Expand
National Institutes of Health

Related topics

Related topics

3 relations
DNA RepairDNA Repair GenePARP1 gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis.
OBJECTIVE Autophagy is a process for turnover of intracellular organelles and molecules that protects cells during stress… Expand
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Highly Cited
2010
Highly Cited
2010
Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.
Evidence suggests that tumor microenvironment is critically involved in supporting survival of chronic lymphocytic leukemia (CLL… Expand
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Highly Cited
2008
Highly Cited
2008
An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based…
The potential inhibitory effects of 3 excipients (polyethylene glycol [PEG] 400, Pluronic P85, and vitamin E d-a-tocopheryl… Expand
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2008
2008
Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential…
The Hodgkin cells and Reed-Sternberg cells (HRS) of classical Hodgkin lymphoma (CHL) are derived from germinal center B cells… Expand
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2007
2007
Improvement of the oral drug absorption of topotecan through the inhibition of intestinal xenobiotic efflux transporter, breast cancer resistance protein, by excipients.
Recently, breast cancer resistance protein (BCRP/ABCG2) has been shown to limit the oral absorption of its substrates in the… Expand
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Highly Cited
2006
Highly Cited
2006
Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis.
OBJECTIVE To examine the therapeutic efficacy of caspase inhibitors in experimental osteoarthritis (OA). METHODS Experimental… Expand
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Highly Cited
2004
Highly Cited
2004
Effect of Pluronic P85 on ATPase Activity of Drug Efflux Transporters
No HeadingPurpose.Pluronic block copolymers are potent sensitizers of multidrug resistant (MDR) cancer cells. The sensitization… Expand
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Highly Cited
2004
Highly Cited
2004
Pluronic P85 Increases Permeability of a Broad Spectrum of Drugs in Polarized BBMEC and Caco-2 Cell Monolayers
AbstractPurpose. Previous studies demonstrated that inhibition of P glycoprotein (P-gp) by Pluronic P85 (P85) block copolymer… Expand
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Highly Cited
2001
Highly Cited
2001
Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion
This paper, for the first time, demonstrates that exposure of cells to the poly(ethylene oxide)-poly(propylene oxide) block… Expand
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Highly Cited
1996
Highly Cited
1996
Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer.
The chemosensitizing effect of Pluronic P85 block copolymer were studied using two human ovarian carcinoma sublines: the… Expand
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