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Pleckstrin Homology Domains

Known as: Domain, Pleckstrin Homology, Homology Domains, Pleckstrin, PH Domains 
Pleckstrin-homology (PH) domains are protein modules of approximately 120 amino acids found in a wide variety of signaling proteins in organisms… 
National Institutes of Health

Related topics

Related topics

45 relations
AKAP13 protein, humanAKT2 protein, humanAKT3 protein, humanAPS protein, human

Papers overview

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Highly Cited
2007
Highly Cited
2007
Gαq Directly Activates p63RhoGEF and Trio via a Conserved Extension of the Dbl Homology-associated Pleckstrin Homology Domain*
The coordinated cross-talk from heterotrimeric G proteins to Rho GTPases is essential during a variety of physiological processes… 
Review
2004
Review
2004
Membrane targeting by pleckstrin homology domains.
Pleckstrin homology (PH) domains are small modular domains that occur once, or occasionally several times, in a large variety of… 
Highly Cited
2003
Highly Cited
2003
The Pleckstrin Homology Domain of Phospholipase C-β2 as an Effector Site for Rac*
Increasing evidence links the activation of Rho family GTPases to the stimulation of lipid hydrolysis catalyzed by phospholipase… 
Highly Cited
1998
Highly Cited
1998
IRS Pleckstrin Homology Domains Bind to Acidic Motifs in Proteins*
Using a yeast two-hybrid system, we identified several proteins that interact with the PH domains in IRS-1 and IRS-2, including… 
Highly Cited
1997
Highly Cited
1997
Interactions between Protein Kinase C and Pleckstrin Homology Domains
Pleckstrin homology (PH) domains comprised of loosely conserved sequences of ∼100 amino acid residues are a functional protein… 
Highly Cited
1997
Highly Cited
1997
Cloning, Chromosome Localization, Expression, and Characterization of an Src Homology 2 and Pleckstrin Homology Domain-containing Insulin Receptor Binding Protein hGrb10γ*
hGrb10α (previously named Grb-IR) is a Src-homology 2 domain-containing protein that binds with high affinity to the tyrosine… 
Highly Cited
1995
Highly Cited
1995
Effect of Cellular Expression of Pleckstrin Homology Domains on Gi-coupled Receptor Signaling(*)
Pleckstrin homology (PH) domains are 90-110 amino acid regions of protein sequence homology that are found in a variety of… 
Highly Cited
1994
Highly Cited
1994
Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.
Bruton tyrosine kinase (Btk) has been implicated as the defective gene in both human and murine B-cell deficiencies. The… 
1994
1994
Structure of the pleckstrin homology domain from beta-spectrin.
The 'pleckstrin homology' or PH domain is a 100-residue protein module. It is present in many kinases, different isoforms of… 
Highly Cited
1993
Highly Cited
1993
Identification of novel pleckstrin homology (PH) domains provides a hypothesis for PH domain function.
Pleckstrin homology (PH) domains are difficult to find in protein sequence databases with widely used computer programs. A simple… 
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