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Pirarubicin

Known as: Adriamycin, tetrahydropyranyl, THP-adriamycin, (2"R)-4'-O-Tetrahydropyranyladriamycin 
An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

Antineoplastic AgentsDoxorubicin
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (4)

PinorubicinTheprubicinpirarubicin hydrochloridetherarubicin

Papers overview

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2012
2012
The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells.
Highly Cited
2010
Highly Cited
2010
In vitro and in vivo evaluation of tumor targeting styrene‐maleic acid copolymer‐pirarubicin micelles: Survival improvement and inhibition of liver metastases
Pirarubicin is a derivative of doxorubicin with improved intracellular uptake and reduced cardiotoxicity. We have prepared a… 
Highly Cited
2007
Highly Cited
2007
Prospective study of a pirarubicin, intermediate-dose cytarabine, and etoposide regimen in children with Down syndrome and acute myeloid leukemia: the Japanese Childhood AML Cooperative Study Group.
PURPOSE To evaluate a less intensive chemotherapeutic regimen specifically designed for patients with Down syndrome (DS) and… 
Highly Cited
2005
Highly Cited
2005
Adriamycin(hydrazone)-antibody conjugates require internalization and intracellular acid hydrolysis for antitumor activity
SummaryAdriamycin hydrazone (ADM-Hzn) immunoconjugates have previously been shown to exhibit antibody-directed antitumor activity… 
Review
2004
Review
2004
TRAIL and chemotherapeutic drugs in cancer therapy.
Highly Cited
1997
Highly Cited
1997
Doxorubicin sensitizes human bladder carcinoma cells to Fas‐mediated cytotoxicity
The resistance of bladder carcinoma to anticancer chemotherapeutic agents remains a major problem. Hence, several… 
1996
1996
Pyrazole-related nucleosides. 4. Synthesis and antitumor activity of some 1-tetrahydropyranyl-4-substituted pyrazoles.
Continuing our studies on the structure-activity relationships of some pyrazole nucleosides (1a-h) structurally related to… 
Highly Cited
1989
Highly Cited
1989
Comparative cytotoxicity, DNA synthesis inhibition and drug incorporation of eight anthracyclines in a model of doxorubicin-sensitive and -resistant rat glioblastoma cells.
1988
1988
Anthracycline-induced DNA breaks and resealing in doxorubicin-resistant murine leukemic P388 cells.
Highly Cited
1986
Highly Cited
1986
Flow cytometric monitoring of cellular anthracycline accumulation in murine leukemic cells.
Cellular accumulation of daunorubicin (DNR), N-trifluoroacetyl-adriamycin-14-valerate, and THP-Adriamycin (THP-ADR) in… 
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