Phosphoglycerate dehydrogenase

Known as: Dehydrogenase, Phosphoglycerate, Oxidoreductase, Phosphoglycerate, Dehydrogenase, D-3-Phosphoglycerate 
An enzyme that catalyzes the oxidation of 3-phosphoglycerate to 3-phosphohydroxypyruvate. It takes part in the L-SERINE biosynthesis pathway.
National Institutes of Health

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D-3-Phosphoglycerate Dehydrogenase, humanIn BloodPHGDH genePHGDH wt Allele
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Papers overview

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2014
2014
Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate
Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified… (More)
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2008
2008
Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase.
The crystal structure of Mycobacterium tuberculosis d-3-phosphoglycerate dehydrogenase has been solved with bound effector, l… (More)
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2004
2004
Multiconformational states in phosphoglycerate dehydrogenase.
Phosphoglycerate dehydrogenase (PGDH) catalyzes the first step in the serine biosynthetic pathway. In lower plants and bacteria… (More)
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Highly Cited
2003
Highly Cited
2003
Candida albicans binds human plasminogen: identification of eight plasminogen-binding proteins.
Several microbial pathogens augment their invasive potential by binding and activating human plasminogen to generate the… (More)
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Highly Cited
2001
Highly Cited
2001
The ACT domain family.
A novel ligand-binding domain, named the 'ACT domain', was recently identified by a PSI-BLAST search. The archetypical ACT domain… (More)
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Highly Cited
2000
Highly Cited
2000
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc.
Unlike normal mammalian cells, which use oxygen to generate energy, cancer cells rely on glycolysis for energy and are therefore… (More)
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2000
2000
Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis.
3-phosphoglycerate dehydrogenase (PHGDH) deficiency is a disorder of L-serine biosynthesis that is characterized by congenital… (More)
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1996
1996
A model for the regulation of D-3-phosphoglycerate dehydrogenase, a Vmax-type allosteric enzyme.
Escherichia coli D-3-phosphoglycerate dehydrogenase (ePGDH) is a tetramer of identical subunits that is allosterically inhibited… (More)
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1977
1977
Transient kinetic and deuterium isotope effect studies on the catalytic mechanism of phosphoglycerate dehydrogenase.
The catalytic mechanism of the phosphoglycerate dehydrogenase reaction in both directions was investigated by studying: (a) pre… (More)
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1975
1975
Regulatory properties of purified 3-phosphoglycerate dehydrogenase from Bacillus subtilis.
3-Phosphoglycerate dehydrogenase (3-phosphoglycerate:NAD oxidoreductase, EC. 1.1.1.95) was purified from Bacillus subtilis by… (More)
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