• Publications
  • Influence
The detection of anthelmintic resistance in nematodes of veterinary importance.
Revised and new methods for the detection of anthelmintic resistance in nematodes of ruminants, horses and pigs are provided here with the purpose that they are evaluated internationally to establish whether they could in the future be recommended by the WAAVP. Expand
Drug resistance in veterinary helminths.
Some of the recent findings on resistance mechanisms are summarized, some recommendations for limiting its impact are put forward and some priorities for research in this area are suggested. Expand
Anthelmintic resistance.
Improvements in the understanding of the biochemistry and molecular genetics of anthelmintic actions should lead to the development of more sensitive in vitro assays for the detection of anmalmintic resistance in individual nematodes. Expand
Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog.
The data suggest that a P-glycoprotein may play a role in ivermectin resistance in the sheep nematode parasite Haemonchus contortus and the multidrug resistance reversing agent, verapamil, increased the efficacy of iverMectin and moxidectin against a moxodectin-selected strain of this nematodes in jirds. Expand
The kinetics of triclabendazole disposition in sheep.
To investigate whether the disposition of triclabendazole (TCBZ) and its metabolites in blood or bile influenced its flukicidal potency, TCBZ was administered intraruminally at 10 mg kg-1 to sheepExpand
Genetic variability following selection of Haemonchus contortus with anthelmintics.
  • R. Prichard
  • Biology, Medicine
  • Trends in parasitology
  • 1 September 2001
The genes involved in anthelmintic resistance in H. contortus are compared with those that confer susceptibility or resistance on the free living nematode Caenorhabditis elegans, and the latest knowledge of genes associated with resistance to benzimidazoles, levamisole and the macrocyclic lactones is discussed. Expand
Moxidectin and the avermectins: Consanguinity but not identity.
Differences between MOX and the avermectins are seen in interactions with ABC transporters in mammals and nematodes, and are important for pharmacokinetics, toxicity in animals with defective transporter expression, and probable mechanisms of resistance. Expand
Mutations in the extracellular domains of glutamate‐gated chloride channel α3 and β subunits from ivermectin‐resistant Cooperia oncophora affect agonist sensitivity
Electrophysiological whole‐cell voltage‐clamp recordings showed that mutations in the IVR GLUClα3 caused a modest but significant threefold loss of sensitivity to glutamate, the natural ligand for GluCl receptors, and a significant decrease in sensitivity to the anthelmintics ivermectin and moxidectin was observed in theIVR Gluclα3 receptor. Expand
Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study
The results suggest that resistant adult parasite populations, which are not responding as expected to ivermectin, are emerging and a high rate of repopulation of skin with microfilariae will allow parasite transmission. Expand