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Phosphinic Acids

Known as: Phosphinic acid, Hypophosphorous Acids, Acids, Hypophosphorous 
Inorganic or organic derivatives of phosphinic acid, H2PO(OH). They include phosphinates and phosphinic acid esters.
National Institutes of Health

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(2-formylethyl)phenylphosphinic acid ethyl ester1-amino-3-(methylthio)propylphosphinic acidACE-ECE-1 dual inhibitor FIAZD9343
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2012
Highly Cited
2012
Insights into a surprising reaction: the microwave-assisted direct esterification of phosphinic acids.
It is well-known that phosphinic acids do not undergo direct esterifications with alcohols under thermal conditions. However, the… 
Highly Cited
2011
Highly Cited
2011
TRAP, a powerful and versatile framework for gallium-68 radiopharmaceuticals.
Highly Cited
2007
Highly Cited
2007
Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity.
Highly Cited
2005
Highly Cited
2005
Brønsted acid-catalyzed imine amidation.
A new method for the Brønsted acid-catalyzed addition of amide nucleophiles to imines to produce protected aminal products is… 
Highly Cited
2001
Highly Cited
2001
Triethylborane-initiated room temperature radical addition of hypophosphites to olefins: synthesis of monosubstituted phosphinic acids and esters.
A novel and practical approach to monosubstituted phosphinic acid (alkylphosphonous acid) derivatives from hypophosphite salts or… 
Highly Cited
1995
Highly Cited
1995
Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.
In 1987, 25 years after the synthesis of the potent and selective GABAB agonist baclofen (1), Kerr et al. described the first… 
Highly Cited
1995
Highly Cited
1995
Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
The antispastic agent and muscle relaxant baclofen 1 is a potent and selective agonist for bicuculline-insensitive GABAB… 
Highly Cited
1988
Highly Cited
1988
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.
Analogues of captopril, enalaprilat, and the phosphinic acid [hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline incorporating 4… 
Highly Cited
1987
Highly Cited
1987
Phosphorus amino acid analogues as inhibitors of leucine aminopeptidase.
A variety of phosphorus amino acid and dipeptide analogues have been synthesized and evaluated as inhibitors of the metalloenzyme… 
Highly Cited
1987
Highly Cited
1987
Bacterial carbon-phosphorus lyase: products, rates, and regulation of phosphonic and phosphinic acid metabolism
Carbon-phosphorus bond cleavage activity, found in bacteria that utilize alkyl- and phenylphosphonic acids, has not yet been… 
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