Phosphinic Acids

Known as: Phosphinic acid, Hypophosphorous Acids, Acids, Hypophosphorous 
Inorganic or organic derivatives of phosphinic acid, H2PO(OH). They include phosphinates and phosphinic acid esters.
National Institutes of Health

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(2-formylethyl)phenylphosphinic acid ethyl ester1-amino-3-(methylthio)propylphosphinic acidACE-ECE-1 dual inhibitor FIAZD9343
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In Bloodagonistsantagonists & inhibitorsaspects of radiation effects
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Papers overview

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2012
2012
Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for…
Three phosphinic acid 1,4,7-triazacyclononane (TACN) derivatives bearing methylphosphinic (TRAP-H), methyl(phenyl)phosphinic… (More)
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2009
2009
(R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.
Gastroesophageal reflux disease (GERD) affects >10% of the Western population. Conventionally, GERD is treated by reducing… (More)
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2006
2006
Direct evidence for the availability of reactive, water soluble phosphorus on the early Earth. H-phosphinic acid from the Nantan meteorite.
Anoxic irradiation of a type IIICD iron meteorite known to contain the phosphide mineral schreibersite (Fe,Ni)3P in the presence… (More)
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Highly Cited
2005
Highly Cited
2005
Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area.
We studied neurogliaform neurons in the stratum lacunosum moleculare of the CA1 hippocampal area. These interneurons have short… (More)
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Highly Cited
2002
Highly Cited
2002
Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure.
The mesolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) is involved in many drug-related behaviors… (More)
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2001
2001
Design and pharmacological activity of phosphinic acid based NAALADase inhibitors.
A novel series of phosphinic acid based inhibitors of the neuropeptidase NAALADase are described in this work. This series of… (More)
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1997
1997
Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABAB receptor agonist.
The aim of this study was to reexamine the concept that gamma-hydroxybutyric acid (GHB) is a weak but selective agonist at gamma… (More)
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1995
1995
Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
The antispastic agent and muscle relaxant baclofen 1 is a potent and selective agonist for bicuculline-insensitive GABAB… (More)
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1995
1995
Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.
In 1987, 25 years after the synthesis of the potent and selective GABAB agonist baclofen (1), Kerr et al. described the first… (More)
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1987
1987
Bacterial carbon-phosphorus lyase: products, rates, and regulation of phosphonic and phosphinic acid metabolism.
Carbon-phosphorus bond cleavage activity, found in bacteria that utilize alkyl- and phenylphosphonic acids, has not yet been… (More)
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