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Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist
The present observations strongly support a unique mechanism of action of topiramate, which involves GluR5 kainate receptors, as well as in vitro cellular electrophysiological results, which are consistent with the possibility that the effects ofTopiramate on clonic seizure activity are due to functional blockade of Glamorganic acid receptors. Expand
SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy
The concept that SV2A protein is an important target for both partial and generalized epilepsies and thereby relevant for the generation of new antiepileptic drugs with potential broad-spectrum efficacy is supported. Expand
Benefit of combination therapy in epilepsy: A review of the preclinical evidence with levetiracetam
Combinations of levetiracetam with clinically used AEDs that enhance GABAergic inhibition may be considered for rational polytherapy, which is often necessary in drug‐resistant patients. Expand
Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment
The rationale for the discovery and preclinical profile of brivaracetam (BRV), currently under regulatory review as adjunctive therapy for adults with partial‐onset seizures, is described and it is revealed BRV had a greater antiepileptogenic potential than LEV. Expand
Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy
Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for epilepsy, because single target therapies areExpand
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease
A systems-level analysis of genome-wide gene expression data is performed to infer gene-regulatory networks conserved across species and brain regions, and two networks, M1 and M3, showed replicable enrichment for common genetic variants underlying healthy human cognitive abilities, including memory. Expand
Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization
It is highlighted that the pilocarpine model of TLE in mice is associated with brain pathology akin to different stages of human disease and may provide a valuable tool for the discovery of future antiepileptic drugs with disease-modifying properties. Expand
Opportunities for improving animal welfare in rodent models of epilepsy and seizures
This report provides background information and recommendations aimed at minimising pain, suffering and distress in rodent models of epilepsy and seizures in order to improve animal welfare and optimise the quality of studies in this area. Expand
Genetic deletion of the norepinephrine transporter decreases vulnerability to seizures
Support is provided for a role of endogenous NE in the control of seizure susceptibility by using NE transporter knock-out mice, which are characterized by high levels of extracellular NE. Expand
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target
A general computational gene regulatory framework called CRAFT for drug target discovery is described, and the authors use CRAFT to identify the microglial membrane receptor Csf1R as a potential therapeutic target for epilepsy. Expand