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Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3, human

Known as: PI3-Kinase Type 3, PI3K Type 3, PtdIns-3-Kinase Type 3 
Phosphatidylinositol 3-kinase catalytic subunit type 3 (887 aa, ~102 kDa) is encoded by the human PIK3C3 gene. This protein plays a role in the… 
National Institutes of Health

Related topics

Related topics

13 relations
AutophagyAutophagy Regulation PathwayCytokinesisEnzyme Gene

Broader (1)

Class III Phosphatidylinositol 3-Kinase Catalytic Subunit

Papers overview

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Review
2012
Review
2012
14-3-3 Proteins are Regulators of Autophagy
14-3-3 proteins are implicated in the regulation of proteins involved in a variety of signaling pathways. 14-3-3-dependent… 
Highly Cited
2011
Highly Cited
2011
Phospholipase D Mediates Nutrient Input to Mammalian Target of Rapamycin Complex 1 (mTORC1)*
The mammalian target of rapamycin (mTOR) is a critical sensor of nutritional sufficiency. Although much is known about the… 
Review
2011
Review
2011
Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism
Purpose of reviewTo highlight the recent research pertaining to the cellular mechanisms linking amino acid availability, mTORC1… 
Highly Cited
2011
Highly Cited
2011
Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase
14-3-3s are binding proteins with survival functions in cells by interaction with proteins involved in the regulation of cell… 
Highly Cited
2010
Highly Cited
2010
Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.
Melanoma differentiation-associated gene 7 (mda-7)/interleukin-24 (IL-24) is a unique member of the IL-10 gene family, which… 
Highly Cited
2010
Highly Cited
2010
The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression*
The class III phosphatidylinositol 3-kinase (PI3KC3) plays a central role in autophagy. Rubicon, a RUN domain-containing protein… 
Highly Cited
2007
Highly Cited
2007
Regulation of class III (Vps34) PI3Ks.
The class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first identified as a regulator of… 
Highly Cited
2007
Highly Cited
2007
The Inositol Trisphosphate Receptor in the Control of Autophagy
The second messenger myo-inositol-1,4,5-trisphosphate (IP3) acts on the IP3 receptor (IP3R), an IP3-activated Ca2+ channel of the… 
Highly Cited
2005
Highly Cited
2005
hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase*
Mammalian cells respond to nutrient deprivation by inhibiting energy consuming processes, such as proliferation and protein… 
Highly Cited
2002
Highly Cited
2002
Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome
PI 3‐kinases are important regulators of endocytic trafficking. We have previously proposed a model in which the Rab5 GTPase… 
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