Share This Author
Resistance exercise increases AMPK activity and reduces 4E‐BP1 phosphorylation and protein synthesis in human skeletal muscle
- H. Dreyer, S. Fujita, J. Cadenas, D. Chinkes, E. Volpi, B. Rasmussen
- BiologyThe Journal of physiology
- 1 October 2006
It is concluded that AMPK activation and a reduced phosphorylation of 4E‐BP1 may contribute to the inhibition of muscle protein synthesis during resistance exercise.
Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise.
- K. Tipton, B. Rasmussen, R. Wolfe
- Biology, MedicineAmerican journal of physiology. Endocrinology and…
- 1 August 2001
The results indicate that the response of net muscleprotein synthesis to consumption of an EAC solution immediately before resistance exercise is greater than that when the solution is consumed after exercise, primarily because of an increase in muscle protein synthesis as a result of increased delivery of amino acids to the leg.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise.
- B. Rasmussen, K. Tipton, S. L. Miller, S. Wolf, R. Wolfe
- MedicineJournal of applied physiology
- 1 February 2000
It is concluded that essential amino acids with carbohydrates stimulate muscle protein anabolism by increasing muscle protein synthesis when ingested 1 or 3 h after resistance exercise.
Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging.
It is concluded that the acute MPS response after resistance exercise and EAA ingestion is similar between young and old men; however, the response is delayed with aging.
Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle.
- H. Dreyer, M. Drummond, B. Rasmussen
- BiologyAmerican journal of physiology. Endocrinology and…
- 1 February 2008
The data suggest that enhanced activation of the mTOR signaling pathway is playing a role in the greater synthesis of muscle proteins when resistance exercise is followed by EAA+CHO ingestion.
Dietary protein recommendations and the prevention of sarcopenia
Clinicians should stress the importance of ingesting a sufficient amount of protein with each meal to preserve skeletal muscle mass in ageing and propose a novel and specific dietary approach to prevent or slow down muscle loss with ageing.
Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men.
Low-intensity RE in combination with BFR enhances mTORC1 signaling and MPS in older men and is a novel intervention that may enhance muscle rehabilitation to counteract sarcopenia.
Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis.
The activation of the mTOR signaling pathway appears to be an important cellular mechanism that may help explain the enhanced muscle protein synthesis during REFR.
The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly.
- E. Volpi, B. Mittendorfer, B. Rasmussen, R. Wolfe
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 December 2000
The response of muscle protein anabolism to hyperaminoacidemia with endogenous hyperinsulinemia is impaired in healthy elderly due to the unresponsiveness of protein synthesis.