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Phenytoin sodium

Known as: Sodium Diphenylhydantoinate, diphenylhydantoin sodium, 5,5-Diphenyl-2,4-imidazolidinedione, Monosodium Salt 
The sodium salt form of phenytoin, a hydantoin derivate and non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin sodium promotes… 
National Institutes of Health

Related topics

Related topics

20 relations
Antiepileptic AgentsDrug AllergyEpidermolysis BullosaEpilepsy

Narrower (4)

DihydanDilantinEpanutinEuthasol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1999
Review
1999
Guidelines for nonemergency use of parenteral phenytoin products: proceedings of an expert panel consensus process. Panel on Nonemergency Use of Parenteral Phenytoin Products.
This document summarizes the proceedings of an expert panel consensus process addressing the nonemergency use of parenteral… 
Highly Cited
1983
Highly Cited
1983
Low-melting phenytoin prodrugs as alternative oral delivery modes for phenytoin: a model for other high-melting sparingly water-soluble drugs.
Phenytoin is a high-melting, weakly acidic, and sparingly water-soluble drug. Because of these physicochemical properties… 
Highly Cited
1980
Highly Cited
1980
The neurotoxicity of misonidazole: potential modifying role of phenytoin sodium and dexamethasone.
The dose-limiting effect of the hypoxic-cell sensitizer misonidazole is neurotoxicity, manifested primarily by peripheral… 
Review
1979
Review
1979
Bioavailability of Phenytoin: Clinical Pharmacokinetic and Therapeutic Implications
SummaryPhenytoin (diphenylhydantoin) is still the most commonly used anticonvulsant drug. It has certain physicochemical… 
1973
1973
The renal handling of diphenylhydantoin and 5‐(p‐hydroxyphenyl)‐5‐phenylhydantoin
The renal clearances of diphenylhydantoin (DPH) and its maior metabolite, 5‐(p‐hydroxyphenyl)‐5‐phenylhydantoin (HPPH) have been… 
Highly Cited
1972
Highly Cited
1972
Uptake and binding of catecholamines. Effect of diphenylhydantoin and a new mechanism of action.
Diphenylhydantoin altered the uptake and binding of catecholamines in rat brain. This effect has not been reported previously. In… 
Review
1968
Review
1968
Epilepsy in Jerusalem, Israel
Epileptic disorders of unknown cause in Jerusalem, Israel, which were diagnosed during the period January, 1958, through December… 
1967
1967
Protection from Digitalis Toxicity with the Prophylactic Use of Diphenylhydantoin Sodium An Arrhythmic‐Inotropic Dissociation
Diphenylhydantoin sodium (Dilantin) given prophylactically increased the dose of digitalis necessary to produce toxicity by 72 to… 
1961
1961
Syndrome simulatingqymphosarcoma induced by diphenylhydantoin sodium.
The hydantoin derivatives and analogues may, in sensitive patients, induce a syndrome which so closely mimics lymphosarcoma, both… 
Highly Cited
1950
Highly Cited
1950
Effects of diphenylhydantoin sodium (dilantin sodium) and phenobarbital sodium upon ectopic ventricular tachycardia in acute myocardial infarction.
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