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Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
TLDR
Evidence from nonrandomized studies and everyday clinical experience does indicate that measuring serum concentrations of old and new generation antiepileptic drugs (AEDs) can have a valuable role in guiding patient management provided that concentrations are measured with a clear indication and are interpreted critically, taking into account the whole clinical context.
Rufinamide: Clinical pharmacokinetics and concentration–response relationships in patients with epilepsy
TLDR
Rufinamide is a new, orally active antiepileptic drug (AED), which has been found to be effective in the treatment of partial seizures and drop attacks associated with the Lennox‐Gastaut syndrome and a positive correlation has been identified between reduction in seizure frequency and steady‐state plasma ruf inamide concentrations.
Benzodiazepines in epilepsy: pharmacology and pharmacokinetics
TLDR
Among these BZDs, clorazepate has a unique profile that includes a long half‐life of its active metabolite and slow onset of tolerance, which could theoretically help minimize adverse events.
Epidemiological and medical aspects of epilepsy in the elderly
A comparison of rectal diazepam gel and placebo for acute repetitive seizures.
TLDR
Rectal diazepam gel, administered at home by trained care givers, is an effective and well-tolerated treatment for acute repetitive seizures.
A review of intranasal formulations for the treatment of seizure emergencies.
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.
TLDR
In the context of benzodiazepine-refractory convulsive status epilepticus, the anticonvulsant drugs levetiracetam, fosphenytoin, and valproate each led to seizure cessation and improved alertness by 60 minutes in approximately half the patients, and the three drugs were associated with similar incidences of adverse events.
N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases
TLDR
This work shows the potential utility of MRS monitoring, which could assist in determining dosing regimens for clinical trials of this potentially useful antioxidant therapy for PD disease, GD, and other neurodegenerative disorders.
A Single‐Blind, Crossover Comparison of the Pharmacokinetics and Cognitive Effects of a New Diazepam Rectal Gel with Intravenous Diazepam
TLDR
The aim of this study was to compare the pharmacokinetics and cognitive effects of a new diazepam rectal gel (Diastat®) with intravenously administered DZP.
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