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Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
Although no randomized studies have demonstrated a positive impact of therapeutic drug monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies and everyday clinical… Expand
Rufinamide: Clinical pharmacokinetics and concentration–response relationships in patients with epilepsy
Rufinamide is a new, orally active antiepileptic drug (AED), which has been found to be effective in the treatment of partial seizures and drop attacks associated with the Lennox‐Gastaut syndrome.… Expand
Benzodiazepines in epilepsy: pharmacology and pharmacokinetics
Benzodiazepines (BZDs) remain important agents in the management of epilepsy. They are drugs of first choice for status epilepticus and seizures associated with post‐anoxic insult and are also… Expand
Epidemiological and medical aspects of epilepsy in the elderly
Both the incidence and prevalence of epilepsy are high among the elderly. Cerebrovascular disease is the most common underlying cause, although as many as 25-40% of new epilepsy cases in the elderly… Expand
A comparison of rectal diazepam gel and placebo for acute repetitive seizures.
BACKGROUND Acute repetitive seizures are readily recognizable episodes involving increased seizure frequency. Urgent treatment is often required. Rectal diazepam gel is a promising therapy. METHODS… Expand
A review of intranasal formulations for the treatment of seizure emergencies.
- M. Kapoor, J. Cloyd, R. Siegel
- Journal of controlled release : official journal…
- 10 September 2016
Epileptic seizure emergencies are life-threatening conditions, which in their most severe form, status epilepticus, have a high mortality rate if not quickly terminated. Treatment requires rapid… Expand
N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases
Objective This study aimed to determine if the antioxidant N-acetylcysteine (NAC) is able to alter peripheral and central redox capabilities in patients with Parkinson disease (PD) or Gaucher disease… Expand
Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics.
OBJECTIVE To evaluate antiepileptic (AE) use by nursing home residents. DATA SOURCES Medical records for 996 residents from six Minnesota nursing homes (5% of the nursing home residents in the… Expand
Antiepileptic Drug Use in Nursing Home Residents: Effect of Age, Gender, and Comedication on Patterns of Use
Summary: Purpose: Examine antiepileptic drug (AED) use in nursing homes by age, gender, and use of comedication that can interact with AEDs.
Home use of rectal diazepam for cluster and prolonged seizures: efficacy, adverse reactions, quality of life, and cost analysis.
- R. Kriel, J. Cloyd, R. Hadsall, A. Carlson, K. L. Floren, C. Jones-Saete
- Pediatric neurology
From 1982 through 1987, 128 families, who were instructed in the use of rectally administered diazepam (R-DZP) for the treatment of severe epileptic seizures, were surveyed. Sixty-seven families… Expand