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HUMAN ALPHA-1-GLYCOPROTEIN AND ITS INTERACTIONS WITH DRUGS†,‡

TLDR
It can be predicted that in the fulture, rapid automatic methods to measure binding to albumin and/or AAG will routinely be used in drug development and in clinical practice to predict and/ or guide therapy.
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Metabolism and disposition of methylphenidate-14C: studies in man and animals.

TLDR
MEPH- 14 C·HCl was found to be extensively metabolized in man, dog, rat and mouse, and pronounced species differences in the metabolism of the drug were found.
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Clinical Pharmacokinetics of Probenecid

TLDR
There are 2 primary clinical uses for probenecid: as a uricosuric agent in the treatment of chronic gout and as an adjunct to enhance blood levels of antibiotics (such as penicillins and Cephalosporins).
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The binding of ketamine to plasma proteins: Emphasis on human plasma

TLDR
It was shown that binding of K to plasma and albumin is dependent on pH; binding is decreased at pH lower than 7.4 and increased at higher pH; the partition coefficient between an organic phase and buffer was found to be sensitive to small pH changes.
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Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR 30,090.

TLDR
Modification of the quinine molecule resulted in new drugs which were more highly bound and exhibited longer half-lives than quinines, revealed.
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Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites.

TLDR
A number of metabolites and derivatives of DDS were synthesized and tested for their ability to produce methemoglobin and a new metabolite—the monohydroxylamine of 4-acetylamino-4' aminodiphenylsulfone—was also identified.
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A potential clinical use for methylphenidate with tricyclic antidepressants.

TLDR
Seven patients with recurrent refractory psychotic depressive illness were treated with tricyclic antidepressants plus methylphenidate (Ritalin) and the potentiation by methylphenidates may have important implications for the treatment of depression.
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INFLUENCE OF BINDING ON DRUG METABOLISM AND DISTRIBUTION *

TLDR
The purpose is to discuss the significance of binding of drugs to proteins from the parochial view of a clinical pharmacologist, in particular, how binding to plasma proteins influences the fate of drugs in man.
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Disposition of diazoxide in children

TLDR
Pharmacokinetic studies in 4 children with hypo glycemia who required diazoxide therapy revealed a half‐life of the drug in blood of 9.5 to 24 hmlrs, and the plasma half‐ life of 3H‐diazoxide in rats and dogs was much shorter than in man.
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Dose-dependence of drug plasma level decline in dogs.

TLDR
It has been found that for several drugs the rate of disappearance from plasma is dependent on the dose, and the effect of dose has been interpreted as a special case of inhibition, the self-inhibition of metabolism of a drug.
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