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Metabolism and disposition of methylphenidate-14C: studies in man and animals.
Threo - dl -methylphenidate- 14 C·HCl (MEPH- 14 C·HCl) was found to be extensively metabolized in man, dog, rat and mouse. Pronounced species differences in the metabolism of the drug were found. InExpand
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Clinical Pharmacokinetics of Probenecid
SummaryA review of the clinical applications and of the disposition of probenecid in man, including drug interactions, is presented.Probenecid is the classical competitive inhibitor of organic acidExpand
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Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR 30,090.
The overall fate of the quinolinemethanol antimalarial, mefloquine-HCl [WR 142,490, erythro-DL-alpha-(2-piperidyl)-2,9-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride] was investigated in theExpand
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Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites.
As an extension of our in vitro studies [in which we showed that dapsone (DDS) is N-oxidized by rat liver microsomes to its monohydroxylamine and that this metabolite is responsible forExpand
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A potential clinical use for methylphenidate with tricyclic antidepressants.
Seven patients with recurrent refractory psychotic depressive illness were treated with tricyclic antidepressants plus methylphenidate (Ritalin). The effect of methylphenidate appears to involve anExpand
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INFLUENCE OF BINDING ON DRUG METABOLISM AND DISTRIBUTION *
Our purpose is to discuss the significance of binding of drugs to proteins from the parochial view of a clinical pharmacologist. In particular, we intend to evaluate how binding to plasma proteinsExpand
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Disposition of diazoxide in children
Pharmacokinetic studies in 4 children with hypo glycemia who required diazoxide therapy revealed a half‐life of the drug in blood of 9.5 to 24 hmlrs. The blood level of diazoxide in these childrenExpand
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Dose-dependence of drug plasma level decline in dogs.
It has been found that for several drugs the rate of disappearance from plasma is dependent on the dose. For example, the rate of phenylbutazone metabolism is faster after low than after relativelyExpand
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The influence of barbiturates on coumarin plasma levels and prothrombin response.
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The physiological disposition of probenecid, including renal clearance, in man, studied by an improved method for its estimation in biological material.
A more sensitive and specific method for the assay of probenecid in biological material was devised for the study of the physiological disposition of the drug in man. Probenecid was found to beExpand
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