• Publications
  • Influence
Decreased heart rate variability and its association with increased mortality after acute myocardial infarction.
HR variability remained a significant predictor of mortality after adjusting for clinical, demographic, other Holter features and ejection fraction, and a hypothesis to explain this finding is that decreased HR variability correlates with increased sympathetic or decreased vagal tone, which may predispose to ventricular fibrillation. Expand
Frequency Domain Measures of Heart Period Variability and Mortality After Myocardial Infarction
The relation between the heart period variability measures and all-cause mortality, cardiac death, and arrhythmic death before and after adjusting for five previously established postinfarction risk predictors is explored. Expand
Heart Rate Variability: Measurement and Clinical Utility
Electrocardiographic RR intervals fluctuate cyclically, modulated by ventilation, baroreflexes, and other genetic and environmental factors that are mediated through the autonomic nervous system, and are useful for assessing risk of cardiovascular death or arrhythmic events, especially when combined with other tests. Expand
Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on
This multispecialty consensus document reviews the evidence linking depression with CHD and provides recommendations for healthcare providers for the assessment, referral, and treatment of depression. Expand
RR variability in healthy, middle-aged persons compared with patients with chronic coronary heart disease or recent acute myocardial infarction.
Values of RR variability previously reported to predict death in patients with known chronic coronary heart disease are rarely found in healthy middle-aged individuals and should be rare when measures ofRR variability are used to screen groups of middle- aged persons to identify individuals who have substantial risk of coronary deaths or arrhythmic events. Expand
The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction.
Examination of relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality after the occurrence of myocardial infarction in 766 patients who enrolled in a nine-hospital study and underwent two special tests suggested a suggestion of an interaction between each risk variable and time afterinfarction. Expand
Prophylactic use of implanted cardiac defibrillators in patients at high risk for ventricular arrhythmias after coronary-artery bypass graft surgery. Coronary Artery Bypass Graft (CABG) Patch Trial
  • J. Bigger
  • Medicine
  • The New England journal of medicine
  • 1997
No evidence of improved survival is found among patients with coronary heart disease, a depressed left ventricular ejection fraction, and an abnormal signal-averaged electrocardiogram in whom a defibrillator was implanted prophylactically at the time of elective coronary bypass surgery. Expand
Power law behavior of RR-interval variability in healthy middle-aged persons, patients with recent acute myocardial infarction, and patients with heart transplants.
Myocardial infarction or denervation of the heart causes a steeper slope and decreased height of the power law regression relation between log(power) and log(frequency) of RR-interval fluctuations, which makes them excellent predictors of all-cause mortality or arrhythmic death. Expand