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Phenylbutyrates

Known as: Phenylbutyrates [Chemical/Ingredient], phenylbutyrate 
Derivatives of 4-phenylbutyric acid, including its salts and esters.
National Institutes of Health

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Narrower (34)

2-hydroxy-4-phenylbutyric acid2-phenylbutyric acid3-(2,3-dihydroxyphenyl)butyric acid3-amino-2-hydroxy-4-phenylbutanoic acid
Antineoplastic AgentsIn Bloodagonistsantagonists & inhibitors

Broader (2)

Butyratesphenylcarboxylate

Papers overview

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Review
2012
Review
2012
Drug treatment for spinal muscular atrophy types II and III.
BACKGROUND Spinal muscular atrophy (SMA) is caused by degeneration of anterior horn cells, which leads to progressive muscle… 
2010
2010
Phenylbutyrate induces apoptosis and lipid accumulations via a peroxisome proliferator‐activated receptor gamma‐dependent pathway
The effects of the selective peroxisome proliferator activated receptor‐gamma (PPAR‐γ) inhibitor GW9662 on phenylbutyrate (PB… 
2007
2007
Rosiglitazone prevents the progression of preinvasive lung cancer in a murine model.
There is a critical need to identify efficacious chemopreventive agents for lung cancer that can be taken chronically with no… 
2004
2004
New secondary metabolites of phenylbutyrate in humans and rats.
Phenylbutyrate is used to treat inborn errors of ureagenesis, malignancies, cystic fibrosis, and thalassemia. High-dose… 
2002
2002
Identification of phenylbutyrylglutamine, a new metabolite of phenylbutyrate metabolism in humans.
Phenylbutyrate is used in humans for treating inborn errors of ureagenesis, certain forms of cancer, cystic fibrosis and… 
2001
2001
Sodium phenylbutyrate induces apoptosis in human retinoblastoma Y79 cells: the effect of combined treatment with the topoisomerase I-inhibitor topotecan.
Our results demonstrate that sodium phenylbutyrate, a compound with a low degree of toxicity, exerted a cytotoxic effect on human… 
Review
2001
Review
2001
Perspectives in the treatment of malignant gliomas in adults.
Over the last two decades, after establishing the role of postoperative radiotherapy for malignant gliomas, no definitive… 
Highly Cited
2000
Highly Cited
2000
Peroxisome proliferator-activated receptor gamma as a novel target in cancer therapy: binding and activation by an aromatic fatty acid with clinical antitumor activity.
Aromatic fatty acids, of which phenylacetate is a prototype, constitute a class of low toxicity drugs with demonstrated antitumor… 
1996
1996
In vivo nitrogen metabolism in ornithine transcarbamylase deficiency.
We developed a new technique that monitors metabolic competency in female heterozygotes for ornithine transcarbamylase deficiency… 
1955
1955
Inhibition of Lipid Synthesis by Alpha-Phenyl-N-Butyrate and Related Compounds
Summary 1 Alpha-phenyl-n-butyrate at 1 × 10-3 M has been shown to decrease rate of incorporation of acetate-1-C14 into… 
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