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Phenylbutyrates

Known as: Phenylbutyrates [Chemical/Ingredient], phenylbutyrate 
Derivatives of 4-phenylbutyric acid, including its salts and esters.
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
Parkinson disease is caused by the death of midbrain dopamine neurons from oxidative stress, abnormal protein aggregation, and… Expand
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Highly Cited
2009
Highly Cited
2009
Recent evidence suggests that transcriptional dysregulation may play a role in the pathogenesis of amyotrophic lateral sclerosis… Expand
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Highly Cited
2008
Highly Cited
2008
Identification of SOD1 as the mutated protein in a significant subset of familial amyotrophic lateral sclerosis (FALS) cases has… Expand
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Highly Cited
2005
Highly Cited
2005
Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding the huntingtin protein… Expand
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Review
2005
Review
2005
  • C. Monneret
  • European journal of medicinal chemistry
  • 2005
  • Corpus ID: 6312765
Histones are small basic proteins that, by complexing wtih DNA, form the nucleosome core. Repetitive units of this nucleosome led… Expand
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Highly Cited
2005
Highly Cited
2005
Previously, we developed a strategy to develop a novel class of histone deacetylase (HDAC) inhibitors by tethering short-chain… Expand
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Highly Cited
2001
Highly Cited
2001
PURPOSE Sodium phenylbutyrate (PB) demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell… Expand
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Highly Cited
2001
Highly Cited
2001
PURPOSE Phenylbutyrate (PB) is an aromatic fatty acid with multiple mechanisms of action including histone deacetylase inhibition… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Acetylation of DNA-associated histones is linked to activation of gene transcription, whereas histone deacetylation is… Expand
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Highly Cited
1995
Highly Cited
1995
Butyrate analogues have been shown to increase fetal hemoglobin (HbF) production in vitro and in vivo. Sodium phenylbutyrate (SPB… Expand
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