Phenylbutyrates

Known as: Phenylbutyrates [Chemical/Ingredient], phenylbutyrate 
Derivatives of 4-phenylbutyric acid, including its salts and esters.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Parkinson disease is caused by the death of midbrain dopamine neurons from oxidative stress, abnormal protein aggregation, and… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Identification of SOD1 as the mutated protein in a significant subset of familial amyotrophic lateral sclerosis (FALS) cases has… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
PURPOSE To assess the antitumor effects of a novel phenylbutyrate-derived histone deacetylase (HDAC) inhibitor, (S)-HDAC-42, vis… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding the huntingtin protein… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
PURPOSE Phenylbutyrate (PB) is an aromatic fatty acid with multiple mechanisms of action including histone deacetylase inhibition… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
PURPOSE Sodium phenylbutyrate (PB) demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
  • table 4
Is this relevant?
Review
2000
Review
2000
Compounds that inhibit histone deacetylase may enable the re-expression of silenced regulatory genes in neoplastic cells… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
BACKGROUND Acetylation of DNA-associated histones is linked to activation of gene transcription, whereas histone deacetylation is… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Butyrate analogues have been shown to increase fetal hemoglobin (HbF) production in vitro and in vivo. Sodium phenylbutyrate (SPB… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Intravenous arginine butyrate has been shown to increase fetal hemoglobin (HbF) in sickle cell and thalassemia patients. Recently… (More)
  • table 1
  • table 2
  • figure 1
  • figure 3
  • figure 2
Is this relevant?