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HORMONE-SENSITIVE LIPASE AND MONOGLYCERIDE LIPASE ACTIVITIES IN ADIPOSE TISSUE.
TLDR
A lipase activity present in adipose tissue of both rats and rabbits which exhibits a marked specificity for hydrolysis of monoglycerides is investigated and evidence indicating that this activity is distinct from the hormone-sensitive lipase activit’y and probably also from lipoprotein lipase is presented. Expand
Localization of the oxidative defect in phytanic acid degradation in patients with Refsum's disease.
TLDR
These studies support the conclusion that the defect in phytanic acid oxidation in Refsum's disease is located in the first step of phytic acid degradation, that is, in the alpha oxidation step leading to formation of alpha-hydroxyphytanic acid. Expand
Studies on the alpha oxidation of phytanic acid by rat liver mitochondria.
TLDR
The proposed mechanism of mammalian catabolism of phytanic acid involves initial α oxidation leading through α-hydroxyphytanic acid to pristanic acid, and subsequent β oxidations, and the addition of Fe+++ ions greatly stimulates this reaction. Expand
INHIBITORS OF CHOLESTEROL BIOSYNTHESIS AND THE PROBLEM OF HYPERCHOLESTEROLEMIA
Refsum's disease--a recently characterized lipidosis involving the nervous system. Combined clinical staff conference at the National Institutes of Health.
Excerpt Dr. Daniel Steinberg: About the time of World War II, a young Norwegian neurologist, Sigvald Refsum, became intrigued with four patients referred to the Neurology Department of the Rikshosp...
Absorption and metabolism of uniformly 14C-labeled phytol and phytanic acid by the intestine of the rat studied with thoracic duct cannulation.
TLDR
Significant quantities of radioactivity from [14C]phytol (administered to rats with intact thoracic ducts) were excreted in the bile, principally in the form of derivatives much more polar than phytanic acid. Expand
EFFECT OF HORMONES ON LIPOLYSIS AND ESTERIFICATION OF FREE FATTY ACIDS DURING INCUBATION OF ADIPOSE TISSUE IN VITRO.
TLDR
Data are presented suggesting that small amounts of epinephrine, ACTH, or glucagon are largely inactivated during 30 min of incubation with a fat pad under the conditions employed, consonant with the view that the effects of GH on lipolysis in adipose tissue are due to TSH contained in it rather than to ACTH. Expand
Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29.
TLDR
The experiments reported here establish desmosterol (24-dehydrocholesterol) as a major sterol component in the serum, in the liver, and in other tissues of animals treated with MER-29. Expand
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