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Peptidomimetics

Compounds that are designed to mimic the 3D structure of a natural peptide or protein.
National Institutes of Health

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Papers overview

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Review
2017
Review
2017
Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs
The rapid emergence of multidrug-resistant pathogens has evolved into a global health problem as current treatment options are… 
Review
2017
Review
2017
Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer's Disease.
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically accepted treatment to cure or halt its… 
Highly Cited
2017
Highly Cited
2017
Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
The binding of adenomatous polyposis coli (APC) to its receptor Asef relieves the negative intramolecular regulation of Asef and… 
Review
2017
Review
2017
The Potential Therapeutic Application of Peptides and Peptidomimetics in Cardiovascular Disease
Cardiovascular disease (CVD) remains a leading cause of mortality and morbidity worldwide. Numerous therapies are currently under… 
Review
2006
Review
2006
Synthesis and properties of cyclopropane-derived peptidomimetics.
Small peptides exhibit a wide range of biological activities, but although there are some notable exceptions, they are not… 
Highly Cited
2001
Highly Cited
2001
Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake.
Review
1998
Review
1998
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.
Cytochrome P450 3A4 (CYP3A4), the major phase I drug metabolizing enzyme in humans, and the MDR1 gene product P-glycoprotein (P… 
Highly Cited
1997
Highly Cited
1997
Structure–based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor
Exocyclic small peptidomimetics corresponding to three critical binding sites of tumor necrosis factor (TNF)-receptor(l) have… 
Highly Cited
1993
Highly Cited
1993
Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells.
Oncogenic Ras proteins transform animal cells to a malignant phenotype only when modified by farnesyl residues attached to… 
Review
1993
Review
1993
Peptidomimetics derived from natural products
Although much has been written in recent years about rational drug design, no drug has been designed de novo, that is, without… 
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