A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
- Y. Zhang, P. Talalay, C. Cho, G. Posner
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 15 March 1992
Sulforaphane is the most potent inducer, and the presence of oxygen on sulfur enhances potency, which may be a significant component of the anticarcinogenic action of broccoli.
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
- J. Fahey, Y. Zhang, P. Talalay
- Chemistry, MedicineProceedings of the National Academy of Sciences…
- 16 September 1997
Induction of phase 2 detoxication enzymes [e.g., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protection…
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.
- V. Wacher, J. Silverman, Y. Zhang, L. Benet
- Biology, ChemistryJournal of Pharmacy and Science
- 1 November 1998
There is relatively little data regarding the effects of CYP3A and P-gp on peptide drugs; however, studies with the cyclic peptide immunosuppresant cyclosporine as well as peptidomimetics provide some insight into the impact of these systems on the oral absorption of peptides.
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.
- Y. Zhang, T. Kensler, C. Cho, G. Posner, P. Talalay
- ChemistryProceedings of the National Academy of Sciences…
- 12 April 1994
It is reported that sulforaphane and three synthetic analogues, designed as potent phase 2 enzyme inducers, block the formation of mammary tumors in Sprague-Dawley rats treated with single doses of 9,10-dimethyl-1,2-benzanthracene.
Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells.
- Y. Zhang
- Biology, ChemistryCarcinogenesis
- 1 June 2000
It is strongly suggested that intracellular conjugation of ITCs with GSH is mainly responsible for ITC accumulation, supported by the finding that suppression of dissociation by excess GSH or other thiols blocks accumulation of the conjugates.
Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.
- Y. Zhang, P. Talalay
- Chemistry, BiologyCancer Research
- 1 April 1994
Since isothiocyanates block carcinogenesis by dual mechanisms and are already present in substantial quantities in human diets, these agents are ideal candidates for the development of effective chemoprotection of humans against cancer.
Chemical and molecular regulation of enzymes that detoxify carcinogens.
- T. Prestera, W. D. Holtzclaw, Y. Zhang, P. Talalay
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 April 1993
The molecular mechanisms of these inductions were analyzed with the help of a construct containing a 41-bp enhancer element derived from the 5' upstream region of the mouse liver glutathione transferase Ya subunit gene, and inserted into a plasmid containing a human growth hormone reporter gene.
Chemoprotection against cancer by phase 2 enzyme induction.
- P. Talalay, J. Fahey, W. D. Holtzclaw, T. Prestera, Y. Zhang
- Biology, ChemistryToxicology Letters
- 1 December 1995
Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes.
- Y. Zhang, P. Talalay
- Biology, ChemistryCancer Research
- 15 October 1998
Observations suggest strongly that induction of Phase 2 enzymes depends on intracellular levels of isothiocyanates/dithiocarbamates and that glutathione may play several roles in the induction process.
The electrophile counterattack response: protection against neoplasia and toxicity.
- T. Prestera, Y. Zhang, S. R. Spencer, C. Wilczak, P. Talalay
- BiologyAdvances in Enzyme Regulation
- 1993
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