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Chemotaxonomy of the Oleaceae: iridoids as taxonomic markers.
The distribution and biosynthesis of iridoid glucosides in the Oleaceae is reviewed and five distinct biosynthetic pathways to iridoids have been identified in the family, deoxyloganic acid… Expand
Chemotaxonomy of Plantago. Iridoid glucosides and caffeoyl phenylethanoid glycosides.
- N. Rønsted, E. Gobel, H. Franzyk, S. R. Jensen, C. Olsen
- Medicine, Biology
- 1 October 2000
Data for 34 species of Plantago (Plantaginaceae), including subgen. Littorella (= Littorella uniflora), have been collected with regard to their content of iridoid glucosides and caffeoyl… Expand
Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues.
- H. Ziegler, H. Franzyk, +6 authors J. Jaroszewski
- Medicine, Chemistry
- Bioorganic & medicinal chemistry
- 2 January 2004
The natural triterpene betulinic acid and its analogues (betulinic aldehyde, lupeol, betulin, methyl betulinate and betulinic acid amide) caused concentration-dependent alterations of erythrocyte… Expand
Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts.
Nineteen species of Passiflora (Passifloraceae) were examined for the presence of cyanogenic glycosides. Passibiflorin, a bisglycoside containing the 6-deoxy-beta-D-gulopyranosyl residue, was… Expand
Chemotaxonomy and evolution of Plantago L.
- N. Rønsted, H. Franzyk, P. Mølgaard, J. Jaroszewski, S. R. Jensen
- Plant Systematics and Evolution
- 26 November 2003
Abstract.In continuation of our investigations of the genus Plantago L. (Plantaginaceae), sixteen species were investigated with respect to water-soluble glycosides. The iridoids auroside,… Expand
Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo
The T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well established. The identification of the C-type lectin Mincle on innate immune cells as the receptor for… Expand
Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation
ABSTRACTPenetratin is a widely used carrier peptide showing promising potential for mucosal delivery of therapeutic proteins. In the present study, the importance of specific penetratin residues and… Expand
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure.
- J. S. Bahnsen, H. Franzyk, A. Sandberg-Schaal, H. M. Nielsen
- Medicine, Biology
- Biochimica et biophysica acta
- 1 February 2013
Cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs) show great potential as drug delivery vectors and new antibiotic drug entities, respectively. The current study deals with the… Expand
Tailoring cytotoxicity of antimicrobial peptidomimetics with high activity against multidrug-resistant Escherichia coli.
- Rasmus D Jahnsen, Anne Sandberg-Schaal, K. J. Vissing, H. M. Nielsen, N. Frimodt-Møller, H. Franzyk
- Medicine, Chemistry
- Journal of medicinal chemistry
- 20 March 2014
Infections with multidrug-resistant pathogens are an increasing concern for public health. Recently, subtypes of peptide-peptoid hybrids were demonstrated to display potent activity against… Expand
Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo.
- Pernille Nordly, K. Korsholm, +6 authors C. Foged
- Chemistry, Medicine
- European journal of pharmaceutics and…
The combination of delivery systems such as cationic liposomes and immunopotentiating molecules is a promising approach for the rational design of vaccine adjuvants. In this study, a synthetic… Expand