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- Publications
- Influence
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.
- V. Wacher, J. A. Silverman, Y Zhang, L. Benet
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 November 1998
Cytochrome P450 3A4 (CYP3A4), the major phase I drug metabolizing enzyme in humans, and the MDR1 gene product P-glycoprotein (P-gp) are present at high concentrations in villus tip enterocytes of the… Expand
Differentiation of absorption and first‐pass gut and hepatic metabolism in humans: Studies with cyclosporine
The low and variable bioavailability of cyclosporine has been attributed to poor absorption. However, recent studies have suggested that intestinal first‐pass metabolism exerts a significant effect… Expand
The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine
- D. Gómez, V. Wacher, S. Tomlanovich, M. Hebert, L. Benet
- Chemistry, Medicine
- Clinical pharmacology and therapeutics
- 1 July 1995
The pharmacokinetics of cyclosporine were studied in the blood of five normal healthy volunteers (two men and three women) after each received oral and intravenous cyclosporine alone and with… Expand
Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo
- G. Dresser, V. Wacher, S. Wong, Harrison T Wong, D. Bailey
- Chemistry, Medicine
- Clinical pharmacology and therapeutics
- 1 September 2002
Our study was designed to determine the effect of peppermint oil and ascorbyl palmitate on cytochrome P4503A4 (CYP3A4) activity in vitro and oral bioavailability of felodipine in humans.
Grapefruit Juice Activates P-Glycoprotein-Mediated Drug Transport
- A. Soldner, U. Christians, M. Susanto, V. Wacher, J. Silverman, L. Benet
- Chemistry, Medicine
- Pharmaceutical Research
- 1 April 1999
AbstractPurpose. Grapefruit juice (GJ) is known to increase the oral bioavailability of many CYP3A-substrates by inhibiting intestinal phase-I metabolism. However, the magnitude of AUC increase is… Expand
Intestinal drug metabolism and antitransport processes : A potential paradigm shift in oral drug delivery
Poor oral bioavailability for many drugs is generally attributed to poor solubility in the gastrointestinal fluids, poor gut membrane permeability and/or extensive hepatic first-pass elimination.… Expand
Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole.
- V. Wacher, S. Wong, Harrison T Wong
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 2002
Peppermint oil inhibits cyclosporine metabolism in vitro. The current work compared the effects of peppermint oil, ketoconazole, and D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) on… Expand
Pharmacokinetics of tamoxifen after intravenous and oral dosing of tamoxifen-hydroxybutenyl-beta-cyclodextrin formulations.
- C. Buchanan, N. L. Buchanan, +5 authors M. Wempe
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 March 2007
Oral and intravenous administration of tamoxifen base and tamoxifen citrate formulated with hydroxybutenyl-beta-cyclodextrin (HBenBCD) to Sprague-Dawley rats significantly increased the oral… Expand
Sirolimus Oral Absorption in Rats Is Increased by Ketoconazole but Is Not Affected by d-α-Tocopheryl Poly(Ethylene Glycol 1000) Succinate
- V. Wacher, J. Silverman, +6 authors Z. Ramtoola
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 October 2002
The contributions of cytochrome P450 3A (CYP3A) and P-glycoprotein to sirolimus oral bioavailability in rats were evaluated by coadministration of sirolimus (Rapamune) with the CYP3A inhibitor… Expand