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PYRUVATE CARBOXYLASE

Known as: pyruvic carboxylase, Carboxylase, Pyruvate, Pyruvate:carbon-dioxide ligase (ADP-forming) 
A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and… 
National Institutes of Health

Related topics

Related topics

16 relations
In BloodPC genePODXL geneProcess of secretion

Broader (1)

Ligase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase
Background Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1… 
Highly Cited
2013
Highly Cited
2013
Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
We measured the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens and found that only… 
Highly Cited
2011
Highly Cited
2011
Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance
In the heart, detection of hyperpolarized [13C]bicarbonate and 13CO2 by magnetic resonance (MR) after administration of… 
Highly Cited
2010
Highly Cited
2010
Metabolic engineering of Escherichia coli for the production of succinate from glycerol.
Highly Cited
2010
Highly Cited
2010
Nitrate uptake and utilization is modulated by exogenous gamma-aminobutyric acid in Arabidopsis thaliana seedlings.
Highly Cited
2007
Highly Cited
2007
Domain Architecture of Pyruvate Carboxylase, a Biotin-Dependent Multifunctional Enzyme
Biotin-dependent multifunctional enzymes carry out metabolically important carboxyl group transfer reactions and are potential… 
Review
2004
Review
2004
Intercellular metabolic compartmentation in the brain: past, present and future
Highly Cited
2002
Highly Cited
2002
Effects of Growth Mode and Pyruvate Carboxylase on Succinic Acid Production by Metabolically Engineered Strains of Escherichia coli
ABSTRACT Escherichia coli NZN111, which lacks activities for pyruvate-formate lyase and lactate dehydrogenase, and AFP111, a… 
Highly Cited
2002
Highly Cited
2002
A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine…
Early experiments indicated that islet beta-cells substantially metabolized L-alanine but that insulin secretion was largely… 
Review
2002
Review
2002
Biotin in metabolism and its relationship to human disease.
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