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PTTG1 protein, human

Known as: hPTTG protein, TUTR1 protein, human, securin, human 
Securin (202 aa, ~22 kDa) is encoded by the human PTTG1 gene. This protein plays a role in chromosomal maintenance.
National Institutes of Health

Related topics

Related topics

8 relations
Cell CycleCell Cycle ControlGenes, RegulatorGenes, cdc

Broader (1)

Securin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Hepatitis B Virus mRNA-Mediated miR-122 Inhibition Upregulates PTTG1-Binding Protein, Which Promotes Hepatocellular Carcinoma Tumor Growth and Cell Invasion
ABSTRACT As the most abundant liver-specific microRNA, miR-122 is involved in diverse aspects of hepatic function and neoplastic… 
2012
2012
Molecular and Cellular Pathobiology Expression of the PTTG 1 Oncogene Is Associated with Aggressive Clear Cell Renal Cell Carcinoma
The pituitary tumor transforming gene (PTTG1) is a recently discovered oncogene implicated in malignant progression of both… 
Highly Cited
2006
Highly Cited
2006
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.
Overexpression of pituitary tumor-transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the… 
Highly Cited
2005
Highly Cited
2005
Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells
BackgroundPituitary tumor transforming gene1 (PTTG1) is a novel oncogene that is expressed in most tumors. It encodes a protein… 
Highly Cited
2001
Highly Cited
2001
Dual Inhibition of Sister Chromatid Separation at Metaphase
Highly Cited
2001
Highly Cited
2001
Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts
Highly Cited
2001
Highly Cited
2001
Molecular cloning of pituitary tumor transforming gene 1 from ovarian tumors and its expression in tumors.
Highly Cited
2001
Highly Cited
2001
Securin Is Not Required for Chromosomal Stability in Human Cells
Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human… 
Highly Cited
2000
Highly Cited
2000
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
We recently isolated a cDNA for hpttg, the human homolog of rat pituitary tumor transforming gene. Now we have analysed the… 
Highly Cited
1998
Highly Cited
1998
hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG
We have isolated a human cDNA clone encoding a novel protein of 22 kDa that is a human counterpart of the rat oncoprotein PTTG… 
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