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A PGC1-\(\alpha\)-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional coactivator PGC1α Here we show that PGC1αExpand
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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transductionExpand
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Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, theExpand
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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels within a narrow range. Caloric restriction causes many changes in glucose metabolism and extendsExpand
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Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
TLDR
We clarify our preferred target-decoy search strategy by addressing four issues based on observed decoy hit frequencies: (i) the major assumptions made with this database search strategy are reasonable. Expand
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Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia
Microglia are myeloid cells of the CNS that participate both in normal CNS function and in disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs thatExpand
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Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
Despite the success of tyrosine kinase-based cancer therapeutics, for most solid tumors the tyrosine kinases that drive disease remain unknown, limiting our ability to identify drug targets andExpand
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Defining the Human Deubiquitinating Enzyme Interaction Landscape
Deubiquitinating enzymes (Dubs) function to remove covalently attached ubiquitin from proteins, thereby controlling substrate activity and/or abundance. For most Dubs, their functions, targets, andExpand
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A PGC1α-dependent myokine that drives browning of white fat and thermogenesis
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 αExpand
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The impact of microRNAs on protein output
MicroRNAs are endogenous ∼23-nucleotide RNAs that can pair to sites in the messenger RNAs of protein-coding genes to downregulate the expression from these messages. MicroRNAs are known to influenceExpand
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