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PTPN6 wt Allele

Known as: Protein Tyrosine Phosphatase, Non-Receptor Type 6 wt Allele, SHP-1L, HCPH 
Human PTPN6 wild-type allele is located within 12p13 and is approximately 29 kb in length. This allele, which encodes tyrosine-protein phosphatase… 
National Institutes of Health

Related topics

Related topics

15 relations
12p13ApoptosisB Cell Receptor Signaling PathwayCell Differentiation process

Broader (1)

PTPN6 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
Unbalanced production of proinflammatory cytokines and type I interferons in immune responses may lead to immunopathology; thus… 
Highly Cited
2007
Highly Cited
2007
Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells
The activation of signal transducers and activators of transcription 3 (STAT3) has been linked with the proliferation of a… 
Highly Cited
2003
Highly Cited
2003
Vav1 Dephosphorylation by the Tyrosine Phosphatase SHP-1 as a Mechanism for Inhibition of Cellular Cytotoxicity
ABSTRACT Here, we present data suggesting a novel mechanism for regulation of natural killer (NK) cell cytotoxicity through… 
Highly Cited
2003
Highly Cited
2003
The Role of C-terminal Tyrosine Phosphorylation in the Regulation of SHP-1 Explored via Expressed Protein Ligation*
The protein-tyrosine phosphatase SHP-1 plays a variety of roles in the “negative” regulation of cell signaling. The molecular… 
Highly Cited
2001
Highly Cited
2001
Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
Mutations in hepatocyte nuclear factor 1alpha (HNF-1alpha) lead to maturity-onset diabetes of the young type 3 as a result of… 
Highly Cited
2001
Highly Cited
2001
Specific Dephosphorylation of the Lck Tyrosine Protein Kinase at Tyr-394 by the SHP-1 Protein-tyrosine Phosphatase*
The protein-tyrosine phosphatase SHP-1 has been shown to be a negative regulator of multiple signaling pathways in hematopoietic… 
Highly Cited
2000
Highly Cited
2000
Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.
CD33 is a myeloid specific member of the sialic acid-binding receptor family and is expressed highly on myeloid progenitor cells… 
Highly Cited
1999
Highly Cited
1999
Leishmania‐induced increases in activation of macrophage SHP‐1 tyrosine phosphatase are associated with impaired IFN‐γ‐triggered JAK2 activation
Leishmania‐induced macrophage (Mϕ) dysfunctions have been correlated with altered signaling events. Recent findings from our… 
Highly Cited
1998
Highly Cited
1998
Identification of Major Binding Proteins and Substrates for the SH2-Containing Protein Tyrosine Phosphatase SHP-1 in Macrophages
ABSTRACT The protein tyrosine phosphatase SHP-1 is a critical regulator of macrophage biology, but its detailed mechanism of… 
Highly Cited
1998
Highly Cited
1998
Phosphotyrosine 1173 Mediates Binding of the Protein-tyrosine Phosphatase SHP-1 to the Epidermal Growth Factor Receptor and Attenuation of Receptor Signaling*
The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates the epidermal growth factor receptor (EGFR), and both SH2… 
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