PTPN6 wt Allele

Known as: Protein Tyrosine Phosphatase, Non-Receptor Type 6 wt Allele, SHP-1L, HCPH 
Human PTPN6 wild-type allele is located within 12p13 and is approximately 29 kb in length. This allele, which encodes tyrosine-protein phosphatase… (More)
National Institutes of Health

Related topics

Related topics

15 relations
12p13ApoptosisB Cell Receptor Signaling PathwayCell Differentiation process
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Broader (1)

PTPN6 gene

Papers overview

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Highly Cited
2011
Highly Cited
2011
Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma.
BACKGROUND & AIMS Recently, we reported that sorafenib sensitizes hepatocellular carcinoma (HCC) cells to TRAIL through the… (More)
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Highly Cited
2007
Highly Cited
2007
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
The activation of signal transducers and activators of transcription 3 (STAT3) has been linked with the proliferation of a… (More)
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Highly Cited
2003
Highly Cited
2003
Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity.
Here, we present data suggesting a novel mechanism for regulation of natural killer (NK) cell cytotoxicity through inhibitory… (More)
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Highly Cited
2001
Highly Cited
2001
Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
Mutations in hepatocyte nuclear factor 1alpha (HNF-1alpha) lead to maturity-onset diabetes of the young type 3 as a result of… (More)
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Highly Cited
1999
Highly Cited
1999
Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation.
Leishmania-induced macrophage (Mphi) dysfunctions have been correlated with altered signaling events. Recent findings from our… (More)
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Highly Cited
1999
Highly Cited
1999
The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells.
Biliary glycoprotein (Bgp, C-CAM, or CD66a) is an immunoglobulin-like cell adhesion molecule and functions as a tumor suppressor… (More)
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Highly Cited
1998
Highly Cited
1998
Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages.
The protein tyrosine phosphatase SHP-1 is a critical regulator of macrophage biology, but its detailed mechanism of action… (More)
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Highly Cited
1998
Highly Cited
1998
Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling.
The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates the epidermal growth factor receptor (EGFR), and both SH2… (More)
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Highly Cited
1998
Highly Cited
1998
Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.
Interleukin 2 (IL-2) rapidly induces tyrosine phosphorylation of intracellular substrates, including the IL-2 receptor beta chain… (More)
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Highly Cited
1996
Highly Cited
1996
Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1.
Activating mutations in the Kit receptor tyrosine kinase have been identified in both rodent and human mast cell leukemia. One… (More)
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