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PTPN6 wt Allele

Known as: Protein Tyrosine Phosphatase, Non-Receptor Type 6 wt Allele, SHP-1L, HCPH 
Human PTPN6 wild-type allele is located within 12p13 and is approximately 29 kb in length. This allele, which encodes tyrosine-protein phosphatase… 
National Institutes of Health

Related topics

Related topics

15 relations
12p13ApoptosisB Cell Receptor Signaling PathwayCell Differentiation process

Broader (1)

PTPN6 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Anti-CD20 Therapy Acts via Fc g RIIIA to Diminish Responsiveness of Human Natural Killer Cells
Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating Fc g RIIIA/CD16… 
2011
2011
Gambogic Acid Inhibits STAT3 Phosphorylation through Activation of Protein Tyrosine Phosphatase SHP-1: Potential Role in Proliferation and Apoptosis
The transcription factor, STAT3, is associated with proliferation, survival, and metastasis of cancer cells. We investigated… 
Highly Cited
2010
Highly Cited
2010
γ-Tocotrienol but Not γ-Tocopherol Blocks STAT3 Cell Signaling Pathway through Induction of Protein-tyrosine Phosphatase SHP-1 and Sensitizes Tumor Cells to Chemotherapeutic Agents*
Although γ-tocotrienol (T3), a vitamin E isolated primarily from palm and rice bran oil, has been linked with anticancer… 
Highly Cited
2004
Highly Cited
2004
The Neuroprotective Effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a Novel α7 Ligand, Is Prevented through Angiotensin II Activation of a Tyrosine Phosphatase
We have recently provided evidence for nicotine-induced complex formation between the α7 nicotinic acetylcholine receptor (nAChR… 
2001
2001
Insufficient Phosphorylation Prevents FcγRIIB from Recruiting the SH2 Domain-containing Protein-tyrosine Phosphatase SHP-1*
FcγRIIB are IgG receptors that inhibit immunoreceptor tyrosine-based activation motif (ITAM)-dependent cell activation… 
Highly Cited
2000
Highly Cited
2000
The Protein-tyrosine Phosphatase SHP-1 Binds to and Dephosphorylates p120 Catenin*
A prominent tyrosine-phosphorylated protein of ∼100 kDa (designated pp100) in epidermal growth factor (EGF)-stimulated A431 cells… 
Highly Cited
2000
Highly Cited
2000
Perinuclear localization of the protein-tyrosine phosphatase SHP-1 and inhibition of epidermal growth factor-stimulated STAT1/3 activation in A431 cells.
The SH2 domain protein-tyrosine phosphatase SHP-1 has been shown earlier to bind to the epidermal growth factor receptor and to… 
Highly Cited
1997
Highly Cited
1997
Protein-tyrosine Phosphatase SHP-1 Is Dispensable for FcγRIIB-mediated Inhibition of B Cell Antigen Receptor Activation*
The inhibitory Fc receptor, FcγRIIB, provides a signal that aborts B cell antigen receptor activation, blocking extracellular… 
Highly Cited
1997
Highly Cited
1997
Regulation of Src Homology 2-containing Tyrosine Phosphatase 1 during Activation of Human Neutrophils
The tyrosine phosphorylation of several proteins induced in neutrophils by soluble and particulate stimuli is thought to be… 
Highly Cited
1996
Highly Cited
1996
Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation.
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