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PTPN6 wt Allele

Known as: Protein Tyrosine Phosphatase, Non-Receptor Type 6 wt Allele, SHP-1L, HCPH 
Human PTPN6 wild-type allele is located within 12p13 and is approximately 29 kb in length. This allele, which encodes tyrosine-protein phosphatase… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Unbalanced production of proinflammatory cytokines and type I interferons in immune responses may lead to immunopathology; thus… Expand
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Highly Cited
2007
Highly Cited
2007
The activation of signal transducers and activators of transcription 3 (STAT3) has been linked with the proliferation of a… Expand
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Highly Cited
2003
Highly Cited
2003
ABSTRACT Here, we present data suggesting a novel mechanism for regulation of natural killer (NK) cell cytotoxicity through… Expand
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Highly Cited
2003
Highly Cited
2003
The protein-tyrosine phosphatase SHP-1 plays a variety of roles in the “negative” regulation of cell signaling. The molecular… Expand
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Highly Cited
2001
Highly Cited
2001
Mutations in hepatocyte nuclear factor 1alpha (HNF-1alpha) lead to maturity-onset diabetes of the young type 3 as a result of… Expand
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Highly Cited
2001
Highly Cited
2001
The protein-tyrosine phosphatase SHP-1 has been shown to be a negative regulator of multiple signaling pathways in hematopoietic… Expand
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Highly Cited
2000
Highly Cited
2000
CD33 is a myeloid specific member of the sialic acid-binding receptor family and is expressed highly on myeloid progenitor cells… Expand
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Highly Cited
1998
Highly Cited
1998
ABSTRACT The protein tyrosine phosphatase SHP-1 is a critical regulator of macrophage biology, but its detailed mechanism of… Expand
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Highly Cited
1998
Highly Cited
1998
The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates the epidermal growth factor receptor (EGFR), and both SH2… Expand
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Highly Cited
1996
Highly Cited
1996
Activating mutations in the Kit receptor tyrosine kinase have been identified in both rodent and human mast cell leukemia. One… Expand
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