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PTPN6 gene
Known as:
HEMATOPOIETIC CELL PHOSPHATASE
, protein tyrosine phosphatase, non-receptor type 6
, PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 6
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This gene plays a role in the regulation of multiple signaling pathways in hematopoietic cells.
National Institutes of Health
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Related topics
Related topics
11 relations
Apoptosis
Cell Differentiation process
Cell Proliferation
Dephosphorylation
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PTPN6 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Biology of Human Tumors TMEFF 2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome
T. Sun
,
W. Du
,
+14 authors
J. Fang
2014
Corpus ID: 31586674
Purpose: The role and clinical implication of the transmembrane protein with EGF and two follistatin motifs 2 (TMEFF2) in gastric…
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2014
2014
Pin Wang Dendritic Cell Differentiation The STAT 3-Binding Long Noncoding RNA lnc-DC Controls Human
Allyson K. Friedman
,
J. Walsh
,
+9 authors
Ming-Hu Han
2014
Corpus ID: 207777933
, 310 (2014); 344 Science et al. Pin Wang Dendritic Cell Differentiation The STAT3-Binding Long Noncoding RNA lnc-DC Controls…
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2012
2012
B cells: Selecting the best, without BCR signalling
O. Leavy
Nature reviews. Immunology
2012
Corpus ID: 28525202
Germinal centre B cells are responsive to BCR stimulation only in the cell cycle G2 phase.
2012
2012
Cancers Depleted − Kinase / Phosphatase : Potential for Targeting SHP-1 Genetic Screening for Synthetic Lethal Partners of Polynucleotide
T. Mereniuk
,
R. Maranchuk
,
+6 authors
M. Weinfeld
2012
Corpus ID: 207787546
A genetic screen using a library of 6,961 siRNAs led to the identification of SHP-1 (PTPN6), a tumor suppressor frequently…
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2011
2011
Signaling and Regulation Breast Cancer Cells Proliferation Is Regulated by Tyrosine Phosphatase SHP 1 through c-jun N-Terminal Kinase and Cooperative Induction of RFX-1 and AP-4 Transcription Factors
S. Amin
,
Ashok Kumar
,
Ladan Nilchi
,
K. Wright
,
M. Kozlowski
2011
Corpus ID: 6903036
In this study, we show that proliferation of breast cancer cells is suppressed by IGF-1–activated JNK MAPK pathway. The molecular…
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2006
2006
Effect of siRNA targeting SHP-1 on angiogenesis in hindlimb ischemia
公浩 菅野
,
Sugano Masahiro
2006
Corpus ID: 89520248
2003
2003
Differential Regulation of CXCR 4-mediated T-cell Chemotaxis and Mitogen-activated Protein Kinase Activation by the Membrane Tyrosine Phosphatase , CD 45 *
A. Fernandis
,
Rama P. Cherla
,
R. Ganju
2003
Corpus ID: 34558884
The chemokine receptor CXCR4 and its cognate ligand, stromal cell-derived factor-1 (CXCL12), regulate lymphocyte trafficking and…
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2003
2003
The biology and treatment of ITP: what's next?
S. Mckenzie
2003
Corpus ID: 68881189
Immune thrombocytopenic purpura (ITP) is the result of 2 pathologic processes: loss of tolerance to self-antigen accompanied by…
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Review
2003
Review
2003
Phospholipase C-Contains Introns Shared by src Homology 2 Domains in Many Unrelated Proteins
Charlene M Manning
,
W. Mathews
,
Leah P. Fico
,
J. Thackeray
2003
Corpus ID: 38294922
Many proteins with novel functions were created by exon shuffling around the time of the metazoan radiation. Phospholipase C(PLC…
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1998
1998
The Role of SHP1 as a Tumor Suppressor Gene in Human Mammary
Chuan Gao
1998
Corpus ID: 81983570
Abstract : To investigate the possible involvement of SHP1 in human mammary tumorigenesis, SHP1 was stably transfected into a…
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