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PTPN6 gene

Known as: HEMATOPOIETIC CELL PHOSPHATASE, protein tyrosine phosphatase, non-receptor type 6, PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 6 
This gene plays a role in the regulation of multiple signaling pathways in hematopoietic cells.
National Institutes of Health

Related topics

Related topics

11 relations
ApoptosisCell Differentiation processCell ProliferationDephosphorylation

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PTPN6 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Inappropriate Recruitment and Activity by the Src Homology Region 2 Domain-Containing Phosphatase 1 (SHP1) Is Responsible for Receptor Dominance in the SHIP-Deficient NK Cell1
We have previously demonstrated that the NKR repertoire is profoundly disrupted by SHIP deficiency. This repertoire disruption is… 
Review
2005
Review
2005
Protein kinase structure and function analysis with chemical tools.
Highly Cited
2000
Highly Cited
2000
Impaired Natural Killing of MHC Class I-Deficient Targets by NK Cells Expressing a Catalytically Inactive Form of SHP-11
NK cell function is negatively regulated by MHC class I-specific inhibitory receptors. Transduction of the inhibitory signal… 
Highly Cited
1999
Highly Cited
1999
Definition of the Sites of Interaction between the Protein Tyrosine Phosphatase SHP-1 and CD22*
CD22 phosphorylation is an early event of B cell antigen receptor engagement and results in the recruitment of the negative… 
1998
1998
SHP-1 phosphatase C-terminus interacts with novel substrates p32/p30 during erythropoietin and interleukin-3 mitogenic responses.
SHP-1 protein tyrosine phosphatase is a critical negative regulator of mitogenic signaling, as demonstrated by the heightened… 
Highly Cited
1997
Highly Cited
1997
Protein-tyrosine Phosphatase SHP-1 Is Dispensable for FcγRIIB-mediated Inhibition of B Cell Antigen Receptor Activation*
The inhibitory Fc receptor, FcγRIIB, provides a signal that aborts B cell antigen receptor activation, blocking extracellular… 
Highly Cited
1996
Highly Cited
1996
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase
The association of PTP1C deficiency with the multiplicity of lymphoid cell abnormalities manifested by motheaten (me) and viable… 
Highly Cited
1996
Highly Cited
1996
The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling.
Highly Cited
1993
Highly Cited
1993
Inhibition of the activity of protein tyrosine phosphate 1C by its SH2 domains.
Full-length protein tyrosine phosphatase 1C (PTP1C), the catalytic domain of PTP1C (delta PTP1C), and the N-terminal SH2 domain… 
Highly Cited
1993
Highly Cited
1993
Phorbol ester stimulates the activity of a protein tyrosine phosphatase containing SH2 domains (PTP1C) in HL-60 leukemia cells by increasing gene expression.
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