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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.
Adipocytes secrete a variety of bioactive molecules that affect the insulin sensitivity of other tissues. We now show that the abundance of monocyte chemoattractant protein-1 (MCP-1) mRNA in adiposeExpand
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Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus
Diabetes mellitus is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action. Its pathogenesis involvesExpand
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Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significantExpand
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Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin.
BACKGROUND & AIMS : Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, was recently identified in the rat stomach. We examined the effects of the gastric peptide ghrelin onExpand
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A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion.
Protein tyrosine phosphatases (PTPases), such as SHP-1 and SHP-2, that contain Src homology 2 (SH2) domains play important roles in growth factor and cytokine signal transduction pathways. A proteinExpand
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FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets.
White adipocytes are unique in that they contain large unilocular lipid droplets that occupy most of the cytoplasm. To identify genes involved in the maintenance of mature adipocytes, we expressedExpand
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[Obesity and insulin resistance].
The worldwide epidemic of obesity is a serious threat to public health, because obesity results in insulin resistance, which leads to metabolic syndrome. Obesity is determined by both adipocyte sizeExpand
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Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
Background and aims: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor (GHS-R), is an appetite stimulatory signal from the stomach with structural resemblance to motilin. WeExpand
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Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.
Recent studies of obesity have provided new insights into the mechanisms underlying insulin resistance and metabolic dysregulation. Numerous efforts have been made to identify key regulators ofExpand
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Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
The transcription factor, signal transducer and activator of transcription-3 (STAT-3) contributes to various physiological processes. Here we show that mice with liver-specific deficiency in STAT-3,Expand
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