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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.
TLDR
It is suggested that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice.
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
TLDR
The data implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries as well as in two independent Japanese populations, and the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of β-cell function or the corrected insulin response.
Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin.
TLDR
Ghrelin, which is negatively regulated by leptin and IL-1 beta, is secreted by the stomach and increases arcuate NPY expression, which in turn acts through Y(1) receptors to increase food intake and decrease energy expenditure.
A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion
TLDR
It is suggested that SHPS-1 may be a direct substrate for both tyrosine kinases, such as the insulin receptor kinase or Src, and a specific docking protein for SH2-domain-containing PTPases, and may function in both growth factor- and cell adhesion-induced cell signaling.
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.
TLDR
It is found that angiopoietin-like protein 2 (Angptl2) was secreted by adipose tissue and that its circulating level was closely related to adiposity, systemic insulin resistance, and inflammation in both mice and humans.
Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
TLDR
Gastric peptide ghrelin and GHS-R may be promising therapeutic targets not only for anorexia-cachexia but also for obesity and type 2 diabetes, which are becoming increasingly prevalent worldwide.
[Obesity and insulin resistance].
TLDR
Inflammation in adipose tissues and liver results in systemic insulin resistance, and intervention which decreases inflammation may be useful treatment for insulin resistance.
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets.
TLDR
The results suggest that FSP27 contributes to efficient energy storage in WAT by promoting the formation of unilocular lipid droplets, thereby restricting lipolysis and finding that the nature of lipid accumulation in Wat appears to be associated with maintenance of energy balance and insulin sensitivity.
Characterization of the effects of pancreatic polypeptide in the regulation of energy balance.
TLDR
Observations indicate that PP may influence food intake, energy metabolism, and the expression of hypothalamic peptides and gastric ghrelin.
A Role of Ghrelin in Neuroendocrine and Behavioral Responses to Stress in Mice
TLDR
The findings suggest that ghrelin may have a role in mediating neuroendocrine and behavioral responses to stressors and that the stomach could play an important role, not only in the regulation of appetite, but also in theregulation of anxiety.
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