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PTN protein, human

Known as: HB-GAM, Heparin-Binding Growth Factor 8, HBNF protein, human 
Pleiotrophin (168 aa, ~19 kDa) is encoded by the human PTN gene. This protein is involved in the regulation of both neurite outgrowth and cell… 
National Institutes of Health

Related topics

Related topics

13 relations
Cell Proliferation Regulatory ProcessExtracellular SpaceGrowth FactorGrowth Factor Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Comparative evaluation of the shaping ability of ProTaper Next, iRaCe and Hyflex CM rotary NiTi files in severely curved root canals.
AIM To compare the shaping ability of ProTaper Next, iRaCe and Hyflex CM rotary NiTi files during the preparation of severely… 
Highly Cited
2015
Highly Cited
2015
Micro-computed Tomographic Assessment on the Effect of ProTaper Next and Twisted File Adaptive Systems on Dentinal Cracks.
Highly Cited
2007
Highly Cited
2007
Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) first discovered as the constitutively active nucleophosmin… 
Highly Cited
2006
Highly Cited
2006
Elastic stability and electronic structure of pyrite type PtN2: A hard semiconductor
The elastic properties and electronic structure of PtN2 withthe pyrite structure (PtN2(C2)) were studied with first… 
Highly Cited
2005
Highly Cited
2005
Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts
In skin, fibroblasts of the connective tissue play a decisive role in epidermal homeostasis and repair by contributing to the… 
Highly Cited
2005
Highly Cited
2005
Heparin-binding Growth Factor, Pleiotrophin, Mediates Neuritogenic Activity of Embryonic Pig Brain-derived Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains*
Chondroitin sulfate (CS) and dermatan sulfate (DS) chains play roles in the central nervous system. Most notably, CS/DS hybrid… 
Highly Cited
2002
Highly Cited
2002
Pleiotrophin Signaling through Anaplastic Lymphoma Kinase Is Rate-limiting for Glioblastoma Growth*
Glioblastoma multiforme is the most common highly aggressive human brain cancer, and receptor tyrosine kinases have been… 
Highly Cited
2002
Highly Cited
2002
Increased syndecan expression by pleiotrophin and FGF receptor‐expressing astrocytes in injured brain tissue
Syndecan‐1, ‐2, ‐3, and ‐4 are heparan sulfate proteoglycans that are differentially expressed during development and wound… 
Highly Cited
2000
Highly Cited
2000
Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ
Pleiotrophin (PTN) is a platelet-derived growth factor-inducible, 18-kDa heparin-binding cytokine that signals diverse phenotypes… 
Highly Cited
1998
Highly Cited
1998
Involvement of Receptor-like Protein Tyrosine Phosphatase ζ/RPTPβ and Its Ligand Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM) in Neuronal Migration
Pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) is a specific ligand of protein tyrosine phosphatase ζ (PTP… 
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