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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
These findings provide evidence for the existence of a checkpoint response activated by the nuclear abnormalities caused by prelamin A accumulation, and support the concept that hyperactivation of the tumour suppressor p53 may cause accelerated ageing.
Neurotrophins and the immune system
- J. Vega, O. García-Suárez, J. Hannestad, M. Pérez-Pérez, A. Germanà
- BiologyJournal of anatomy
- 1 July 2003
Results from studies to date support the idea that neurotrophins may regulate some immune functions, and play an important role in the development of the thymus and in the survival of thymocytes.
Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.
- P. Pérez-Piñera, Wei Zhang, Yunchao Chang, J. Vega, T. Deuel
- BiologyThe Journal of biological chemistry
- 28 September 2007
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) first discovered as the constitutively active nucleophosmin-ALK oncoprotein in anaplastic large cell lymphomas (ALCL). Full-length…
Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma.
Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain?
Current knowledge about the innervation of IVDs,NTs and NT receptors, expression of NTs and their receptors in IVDs as well as in the sensory neurons innervating the IVDs are reviewed, the proinflammatory role ofNTs, NTs as nociception regulators, and the potential network of discogenic pain involving NTs are reviewed.
Autophagy is essential for mouse sense of balance.
- G. Mariño, Álvaro F. Fernández, C. López-Otín
- BiologyThe Journal of clinical investigation
- 1 July 2010
An essential role for autophagy is described in inner ear development and equilibrioception and new possibilities for understanding and treating human balance disorders are described, which are of growing relevance among the elderly population.
Aluminum-induced degeneration of astrocytes occurs via apoptosis and results in neuronal death
Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis.
- M. Ståhle-Bäckdahl, B. Sandstedt, C. López-Otín
- Biology, MedicineLaboratory investigation; a journal of technical…
- 1 May 1997
A plausible function for collagenase-3 in these processes is to preferentially degrade type II collagen, thus serving a role during primary ossification, in skeletal remodeling, and in destructive joint disease.
Differential distribution of S100 protein and calretinin in mechanosensory and chemosensory cells of adult zebrafish (Danio rerio)
Pleiotrophin disrupts calcium-dependent homophilic cell–cell adhesion and initiates an epithelial–mesenchymal transition
- P. Pérez-Piñera, S. Alcántara, T. Dimitrov, J. Vega, T. Deuel
- BiologyProceedings of the National Academy of Sciences
- 21 November 2006
It is demonstrated that PTN disrupts cytoskeletal protein complexes, ablates calcium-dependent homophilic cell–cell adhesion, stimulates ubiquitination and degradation of N-cadherin, reorganizes the actin cytoskeleton, and induces a morphological epithelial–mesenchymal transition (EMT) in PTN-stimulated U373 cells.