T. Muramatsu

Publications587
h-index83
Citations23,859
Highly Influential Citations589
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Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse.
TLDR
In Bsg(-/-) mice, there is a severe reduction in accumulation of the MCT 1 and -3 proteins in the RPE and a concomitant reduction in MCT1 and -4 in the neural retina supporting a role for 5A11/basigin in the targeting of these transporters to the plasma membrane.
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Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis.
TLDR
The expression of MK and PTN is increased in various human tumors, making them promising as tumor markers and as targets for tumor therapy, and from the viewpoints of the treatment of neurodegenerative diseases, increasing the efficiency of in vitro development, and the prevention of HIV infection.
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Midkine and pleiotrophin in neural development and cancer.
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A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis.
TLDR
It is suggested that basigin is involved in intercellular recognition during implantation, and an important cell-surface molecule involved in early embryogenesis and reproduction.
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Syndecan-4–dependent Rac1 regulation determines directional migration in response to the extracellular matrix
TLDR
Using nano-engineered fibronectin surfaces and cell-derived matrices, syndecan-4 is identified as a key signaling receptor determining directional migration that mediates the matrix-induced protein kinase Cα–dependent activation of Rac1 and localizes Rac1 activity and membrane protrusion to the leading edge of the cell, resulting in persistent migration.
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Heparan Sulfate Proteoglycans Are Receptors for the Cell-surface Trafficking and Biological Activity of Transglutaminase-2
TLDR
It is proposed that the membrane trafficking of TG2, and hence its extracellular activity, is linked to TG2 binding to cell-surface HSPG.
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Midkine: A Promising Molecule for Drug Development to Treat Diseases of the Central Nervous System
  • T. Muramatsu
  • Biology, Medicine
    Current pharmaceutical design
  • 31 January 2011
TLDR
This review focuses on MK and MK inhibitors as therapeutics for diseases in the central nervous system, and describes the general properties of MK, which are involved in inflammatory diseases by enhancing migration of leukocytes, inducing chemokine production and suppressing regulatory T cells.
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Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily.
TLDR
The specific and limited expression of 5A11/Basigin-2 explicitly within photoreceptor cells implies that this glycoprotein plays a fundamental role within the retina, however, its role remains to be determined.
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A retinoic acid responsive gene MK found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embryogenesis
TLDR
Analysis of MK expression during mouse embryogenesis by in situ hybridization suggests that MK gene plays a fundamental role in the differentiation of a wide variety of cells; MK gene may also play some specific roles in generation of epithelial tissues, and remodeling of mesoderm.
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A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics
TLDR
The novel VEGF blockade system using RNA interference with atelocollagen dramatically suppressed tumor angiogenesis and tumor growth in a PC-3 s.c. xenograft model and provided a beneficial delivering means by which stabilization and efficient transfection of the siRNA injected into the tumors were achieved.
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