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- Publications
- Influence
Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis.
- T. Muramatsu
- Biology, Medicine
- Journal of biochemistry
- 1 September 2002
Midkine (MK) and pleiotrophin (PTN) are low molecular weight proteins with closely related structures. They are mainly composed of two domains held by disulfide bridges, and there are three… Expand
Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse.
- N. Philp, J. Ochrietor, C. Rudoy, T. Muramatsu, P. Linser
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 March 2003
PURPOSE
The neural retina expresses multiple monocarboxylate transporters (MCTs) that are likely to play a key role in the metabolism of the outer retina. Recently, it was reported that targeting of… Expand
Midkine and pleiotrophin in neural development and cancer.
- K. Kadomatsu, T. Muramatsu
- Biology, Medicine
- Cancer letters
- 20 February 2004
The midkine (MK) family consists of only two members, namely heparin-binding growth factors MK and pleiotrophin (PTN). During embryogenesis, MK is highly expressed in the mid-gestational period,… Expand
Cell proliferation, apoptosis and apoptosis-related factors in odontogenic keratocysts and in dentigerous cysts.
- Eisuke Kichi, Y. Enokiya, +4 authors M. Shimono
- Biology, Medicine
- Journal of oral pathology & medicine : official…
- 1 May 2005
BACKGROUND
The purpose of this study was to elucidate why odontogenic keratocysts (OKC) can form cystic lesions but not tumor masses, notwithstanding their prominent proliferative activity.
METHODS… Expand
Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily.
- J. Ochrietor, T. Moroz, +7 authors P. Linser
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 September 2003
PURPOSE
5A11/Basigin has recently been identified as a critical glycoprotein for full maturity and function of the mouse retina. However, the biological function of 5A11/Basigin has yet to be… Expand
Midkine Inhibits Caspase‐Dependent Apoptosis via the Activation of Mitogen‐Activated Protein Kinase and Phosphatidylinositol 3‐Kinase in Cultured Neurons
- K. Owada, N. Sanjo, +4 authors M. Michikawa
- Biology, Medicine
- Journal of neurochemistry
- 1 November 1999
Midkine (MK) is a new member of the heparin-binding neurotrophic factor family. MK plays important roles in development and carcinogenesis and has several important biological effects, including… Expand
Haptotactic Migration Induced by Midkine
- M. Qi, S. Ikematsu, +5 authors K. Kadomatsu
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 11 May 2001
Midkine, a heparin-binding growth factor, plays a critical role in cell migration causing suppression of neointima formation in midkine-deficient mice. Here we have determined the molecules essential… Expand
A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics
- Y. Takei, K. Kadomatsu, Y. Yuzawa, S. Matsuo, T. Muramatsu
- Biology, Medicine
- Cancer Research
- 15 May 2004
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer.… Expand
A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta.
- N. Maeda, K. Ichihara-Tanaka, T. Kimura, K. Kadomatsu, T. Muramatsu, M. Noda
- Chemistry, Medicine
- The Journal of biological chemistry
- 30 April 1999
Midkine is a 13-kDa heparin-binding growth factor with 45% sequence identity to pleiotrophin. Pleiotrophin has been demonstrated to bind to protein-tyrosine phosphatase zeta (PTPzeta) with high… Expand
LDL receptor-related protein as a component of the midkine receptor.
- H. Muramatsu, K. Zou, N. Sakaguchi, S. Ikematsu, S. Sakuma, T. Muramatsu
- Chemistry, Medicine
- Biochemical and biophysical research…
- 21 April 2000
Midkine (MK) is a heparin-binding growth factor with migration-promoting and survival-promoting activities. To identify signaling receptor(s) of MK, membrane glycoproteins with MK-binding activity… Expand