PRNP wt Allele

Known as: ASCR, PrP33-35C, Prion Protein (p27-30) (Creutzfeldt-Jakob Disease, Gerstmann-Strausler-Scheinker Syndrome, Fatal Familial Insomnia) wt Allele 
Human PRNP wild-type allele is located in the vicinity of 20p13 and is approximately 15 kb in length. This allele, which encodes major prion protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2018
0204019792018

Papers overview

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Highly Cited
2004
Highly Cited
2004
Prion diseases are infectious neurodegenerative disorders linked to the accumulation in the central nervous system of the… (More)
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Highly Cited
2001
Highly Cited
2001
Prions are the transmissible pathogenic agents responsible for diseases such as scrapie and bovine spongiform encephalopathy. In… (More)
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Highly Cited
2000
Highly Cited
2000
The cellular prion protein PrPc is a glycosylphosphatidylinositol-anchored cell-surface protein whose biological function is… (More)
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Highly Cited
1996
Highly Cited
1996
ACCUMULATION of the prion protein PrPSc, a pathological and protease-resistant isoform of the normal host protein PrPc, is a… (More)
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Highly Cited
1995
Highly Cited
1995
The cellular form of the prion protein (PrPc) is a glycoprotein anchored to the cell membrane by a glycosylphosphatidylinositol… (More)
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Highly Cited
1995
Highly Cited
1995
After the cellular prion protein (PrPC) transits to the cell surface where it is bound by a glycophosphatidyl inositol (GPI… (More)
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Highly Cited
1994
Highly Cited
1994
THE prion diseases are neurodegenerative conditions, transmissible by inoculation, and in some cases inherited as an autosomal… (More)
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Highly Cited
1993
Highly Cited
1993
S.B. Prusiner proposed that the infectious agent of scraple, the prion, is PrPSc, a modified form of the normal host protein PrPC… (More)
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Highly Cited
1993
Highly Cited
1993
THE cellular prion protein (PrPc) is a sialoglycoprotein of Mr 33–35K that is expressed predominantly in neurons1–3. In… (More)
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Highly Cited
1987
Highly Cited
1987
The scrapie (PrPSc) and cellular (PrPC) prion proteins are encoded by the same gene, and their different properties are thought… (More)
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