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PRNP wt Allele
Known as:
ASCR
, PrP33-35C
, Prion Protein (p27-30) (Creutzfeldt-Jakob Disease, Gerstmann-Strausler-Scheinker Syndrome, Fatal Familial Insomnia) wt Allele
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Human PRNP wild-type allele is located in the vicinity of 20p13 and is approximately 15 kb in length. This allele, which encodes major prion protein…
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National Institutes of Health
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Related topics
Related topics
4 relations
20p13
Creutzfeldt-Jakob disease
Prion Disease Pathway
Broader (1)
PRNP gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
B. Vincent
,
Erwan Paitel
,
+6 authors
Frédéric Checler
Journal of Biological Chemistry
2001
Corpus ID: 30363859
We showed previously that PrPc undergoes constitutive and phorbol ester-regulated cleavage inside the 106-126 toxic domain of the…
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Highly Cited
1999
Highly Cited
1999
Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.
G. Jackson
,
L. Hosszu
,
+7 authors
J. Collinge
Science
1999
Corpus ID: 13032073
Prion propagation involves the conversion of cellular prion protein (PrPC) into a disease-specific isomer, PrPSc, shifting from a…
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Highly Cited
1999
Highly Cited
1999
Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein.
F. Wopfner
,
Georg Weidenhöfer
,
+5 authors
H. Schätzl
Journal of Molecular Biology
1999
Corpus ID: 46280510
Prion diseases are fatal neurodegenerative disorders in man and animal associated with conformational conversion of a cellular…
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Highly Cited
1997
Highly Cited
1997
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.
T. L. James
,
He Liu
,
+8 authors
F. Cohen
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 22767202
The scrapie prion protein (PrPSc) is the major, and possibly the only, component of the infectious prion; it is generated from…
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Highly Cited
1995
Highly Cited
1995
Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells (*)
S. Shyng
,
S. Lehmann
,
K. Moulder
,
D. Harris
Journal of Biological Chemistry
1995
Corpus ID: 27565138
There is currently no effective therapy for human prion diseases. However, several polyanionic glycans, including pentosan…
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Highly Cited
1993
Highly Cited
1993
A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells.
S. Shyng
,
M. Huber
,
D. Harris
Journal of Biological Chemistry
1993
Corpus ID: 5978592
Highly Cited
1992
Highly Cited
1992
Regional mapping of prion proteins in brain.
A. Taraboulos
,
K. Jendroska
,
D. Serban
,
Shu-lian Yang
,
S. DeArmond
,
S. Prusiner
Proceedings of the National Academy of Sciences…
1992
Corpus ID: 45451467
Scrapie is characterized by the accumulation of a protease-resistant isoform of the prion protein PrPSc. Limited proteolysis and…
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Review
1991
Review
1991
A 'unified theory' of prion propagation
C. Weissmann
Nature
1991
Corpus ID: 4367864
There is now very persuasive evidence that the transmissible agent for spongiform encephalopathies such as scrapie, consists of a…
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Highly Cited
1990
Highly Cited
1990
Cellular isoform of the scrapie agent protein participates in lymphocyte activation
N. Cashman
,
R. Loertscher
,
+4 authors
P. Bendheim
Cell
1990
Corpus ID: 23604612
Highly Cited
1986
Highly Cited
1986
The major polypeptide of scrapie‐associated fibrils (SAF) has the same size, charge distribution and N‐terminal protein sequence as predicted for the normal brain protein (PrP).
J. Hope
,
Laura J. D. Morton
,
+4 authors
H. Kimberlin
EMBO Journal
1986
Corpus ID: 11480398
Scrapie‐associated fibrils (SAF) are unique structures characteristic of the group of unconventional slow infections which…
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