Skip to search formSkip to main contentSkip to account menu

PRNP gene

Known as: PRNP, AltPrP, PRION-RELATED PROTEIN 
This gene is involved in prion diseases.
National Institutes of Health

Related topics

Related topics

8 relations
Alternative Prion ProteinCreutzfeldt-Jakob Disease, FamilialCreutzfeldt-Jakob diseaseMajor Prion Protein

Narrower (1)

PRNP wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Transgenic Mice Expressing Porcine Prion Protein Resistant to Classical Scrapie but Susceptible to Sheep Bovine Spongiform Encephalopathy and Atypical Scrapie
Atypical scrapie strain phenotypes may shift when transmitted to a new host. 
Highly Cited
2006
Highly Cited
2006
Probing the Conformation of the Prion Protein within a Single Amyloid Fibril Using a Novel Immunoconformational Assay*
The coexistence of multiple strains or subtypes of the disease-related isoform of prion protein (PrP) in natural isolates… 
Review
2006
Review
2006
Recent advances in clarifying prion protein functions using knockout mice and derived cell lines.
Considerable information on the functions of prion protein (PrP) has been accumulated. One experimental approach is the use of… 
Highly Cited
2004
Highly Cited
2004
Scrapie‐specific neuronal lesions are independent of neuronal PrP expression
In the transmissible spongiform encephalopathies (TSE), accumulation of the abnormal disease‐specific prion protein is associated… 
Highly Cited
2004
Highly Cited
2004
Antigenic characterization of an abnormal isoform of prion protein using a new diverse panel of monoclonal antibodies.
Highly Cited
2003
Highly Cited
2003
Coactivator PRIP, the Peroxisome Proliferator-activated Receptor-interacting Protein, Is a Modulator of Placental, Cardiac, Hepatic, and Embryonic Development*
Nuclear receptor coactivator PRIP (peroxisome proliferator-activated receptor (PPARγ)-interacting protein) and PRIP-interacting… 
Highly Cited
2003
Highly Cited
2003
Association of an 11-12 kDa protease-resistant prion protein fragment with subtypes of dura graft-associated Creutzfeldt-Jakob disease and other prion diseases.
Creutzfeldt-Jakob disease can develop in subjects given a cadaveric dura mater graft (dCJD). This disease has a phenotypic… 
Highly Cited
2002
Highly Cited
2002
Cellular Phenotyping of Secretory and Nuclear Prion Proteins Associated with Inherited Prion Diseases*
The pathogenic mechanisms leading from mutations in the prion protein (PrP) gene to infectious disease are not understood. To… 
Highly Cited
2001
Highly Cited
2001
Flexibility of the murine prion protein and its Asp178Asn mutant investigated by molecular dynamics simulations.
Highly Cited
1992
Highly Cited
1992
Creutzfeldt‐Jakob disease cosegregates with the codon 178Asn PRNP mutation in families of European origin
We recently discovered an amino acid–altering heterozygous mutation in codon 178 of the PRNP amyloid precursor gene in patients… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)