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PRNP gene

Known as: PRNP, AltPrP, PRION-RELATED PROTEIN 
This gene is involved in prion diseases.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Stop codon mutations in the gene encoding the prion protein (PRNP) are very rare and have thus far only been described in two… Expand
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Highly Cited
2005
Highly Cited
2005
The susceptibility of humans to the variant Creutzfeldt-Jakob disease is greatly influenced by polymorphisms within the human… Expand
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Highly Cited
2004
Highly Cited
2004
We report a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died from a non-neurological disorder 5… Expand
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Highly Cited
2003
Highly Cited
2003
Kuru is an acquired prion disease largely restricted to the Fore linguistic group of the Papua New Guinea Highlands, which was… Expand
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Highly Cited
1998
Highly Cited
1998
Classical genetic analysis has identified Sinc/Prni as the major gene controlling mouse scrapie incubation time. Sinc/Prni is… Expand
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Highly Cited
1996
Highly Cited
1996
Deposition of PrP amyloid in cerebral vessels in conjunction with neurofibrillary lesions is the neuropathologic hallmark of the… Expand
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Highly Cited
1996
Highly Cited
1996
The fundamental event in prion diseases seems to be a conformational change in cellular prion protein (PrPC) whereby it is… Expand
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Highly Cited
1995
Highly Cited
1995
Transgenic (Tg) mice expressing human (Hu) and chimeric prion protein (PrP) genes were inoculated with brain extracts from humans… Expand
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Highly Cited
1994
Highly Cited
1994
THE infectious agent (or 'prion') of the transmissible spongiform encephalopathies (TSEs) such as scrapie resembles a virus in… Expand
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Highly Cited
1992
Highly Cited
1992
Infectious scrapie prions are composed largely, if not entirely, of an abnormal isoform of the prion protein (PrP) which is… Expand
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