PRNP gene

Known as: PRNP, AltPrP, PRION-RELATED PROTEIN 
This gene is involved in prion diseases.

Topic mentions per year

Topic mentions per year

1950-2017
05010015019502016

Papers overview

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Review
2016
Review
2016
Prion diseases in humans are neurodegenerative diseases which are caused by an accumulation of abnormal, misfolded cellular prion… (More)
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Highly Cited
2007
Highly Cited
2007
The conformational change of a host protein, PrP(C), into a disease-associated isoform, PrP(Sc), appears to play a critical role… (More)
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Highly Cited
2004
Highly Cited
2004
We report a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died from a non-neurological disorder 5… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Variant Creutzfeldt-Jakob disease (vCJD) has a pathogenesis distinct from other forms of human prion disease: disease… (More)
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Highly Cited
1997
Highly Cited
1997
The normal cellular form of prion protein (PrPC) is a precursor to the pathogenic protease-resistant forms (PrPSc) believed to… (More)
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Highly Cited
1996
Highly Cited
1996
Strains of transmissible spongiform encephalopathies are distinguished by differing physicochemical properties of PrPSc, the… (More)
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Highly Cited
1996
Highly Cited
1996
The 'protein only' hypothesis states that a modified form of normal prion protein triggers infectious neurodegenerative diseases… (More)
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Highly Cited
1996
Highly Cited
1996
We sequenced the prion protein gene and studied the biochemical characteristics and the intracerebral distribution of protease… (More)
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Highly Cited
1996
Highly Cited
1996
The fundamental event in prion diseases seems to be a conformational change in cellular prion protein (PrPC) whereby it is… (More)
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Highly Cited
1994
Highly Cited
1994
We present a synthesis of clinical, neuropathological, and biological details of the National Institutes of Health series of 300… (More)
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