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PPP1R15A wt Allele

Known as: GADD34, Growth Arrest and DNA-Damage-Inducible 34 Gene, Growth Arrest and DNA-Damage-Inducible Gene 34 
Human PPP1R15A wild-type allele is located in the vicinity of 19q13.2 and is approximately 4 kb in length. This allele, which encodes protein… 
National Institutes of Health

Related topics

Related topics

7 relations
19q13.2BMP Receptor Signaling PathwayCellular Stress ResponseNegative Regulation of Cell Cycle

Broader (1)

PPP1R15A gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling
The unfolded protein response (UPR) acts through its downstream branches, PERK-eIF2α signaling, IRE1α-XBP1 signaling and ATF6… 
Highly Cited
2015
Highly Cited
2015
Is there a causal relationship between genetic changes and radiomics-based image features? An in vivo preclinical experiment with doxycycline inducible GADD34 tumor cells.
Highly Cited
2014
Highly Cited
2014
Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis
Highly Cited
2012
Highly Cited
2012
Induction of GADD34 Is Necessary for dsRNA-Dependent Interferon-β Production and Participates in the Control of Chikungunya Virus Infection
Nucleic acid sensing by cells is a key feature of antiviral responses, which generally result in type-I Interferon production and… 
Highly Cited
2009
Highly Cited
2009
An Upstream Open Reading Frame Regulates Translation of GADD34 during Cellular Stresses That Induce eIF2α Phosphorylation*
Cellular stress such as endoplasmic reticulum stress, hypoxia, and viral infection activates an integrated stress response, which… 
Highly Cited
2008
Highly Cited
2008
Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling
Protein misfolding, accumulation, and aggregation characterize many aging-related diseases. Protein aggregates do not accumulate… 
Highly Cited
2006
Highly Cited
2006
Activation and Cross-talk between Akt, NF-κB, and Unfolded Protein Response Signaling in 1-LN Prostate Cancer Cells Consequent to Ligation of Cell Surface-associated GRP78*
Binding of activated forms of the proteinase inhibitor α2-macroglobulin (α2M*) to cell surface-associated GRP78 on 1-LN human… 
Highly Cited
2004
Highly Cited
2004
Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress
ABSTRACT Hypoxic stress results in a rapid and sustained inhibition of protein synthesis that is at least partially mediated by… 
Highly Cited
2003
Highly Cited
2003
Growth Arrest and DNA Damage-Inducible Protein GADD34 Targets Protein Phosphatase 1α to the Endoplasmic Reticulum and Promotes Dephosphorylation of the α Subunit of Eukaryotic Translation Initiation…
ABSTRACT The growth arrest and DNA damage-inducible protein, GADD34, associates with protein phosphatase 1 (PP1) and promotes in… 
Highly Cited
2003
Highly Cited
2003
The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress—elucidation by GADD34‐deficient mice
GADD34 is a protein that is induced by stresses such as DNA damage. The function of mammalian GADD34 has been proposed by in… 
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