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BMP Receptor Signaling Pathway

Known as: BMP signalling pathway, bone morphogenetic protein signalling pathway, BMP receptor signaling 
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a… 
National Institutes of Health

Papers overview

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2019
2019
Introduction Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer in Asian countries, with a… 
2018
2018
OBJECTIVE This study aimed to investigate the role and mechanism of neuropeptide substance P (SP) in ST2 cell (bone mesenchymal… 
Review
2016
Review
2016
Homeobox genes play an overruling role in the regional cell fate determination during development. EVX1 is known as a new target… 
2014
2014
Periodontitis, dis destek dokusu olarak gorev yapan periodonsiyum tabakasinin zarar gormesi sonucu meydana gelen ve yaygin olarak… 
2010
2010
Using two-dimensional gel electrophoresis and MALDI-TOF MS, we identified a protein with a mol wt of 24.5 kD and pI = 7.5 as 1… 
2009
2009
Purpose: Nonmelanoma skin cancer incidence is enhanced >50-fold in patients taking antirejection drugs (ARD) following organ… 
2003
2003
The influence of individual Aegilops longissima addition chromosomes on callus induction and organogenesis of in vitro cultivated… 
Review
2002
Review
2002
............................................................................................................................................8 INTRODUCTION ..................................................................................................................................9 REVIEW OF THE LITERATURE.....................................................................................................10 1. GENERAL CHARACTERISTICS OF THE TRANSFORMING GROWTH FACTOR β SUPERFAMILY.................................................................................................................................10 1.1. Historical background ..............................................................................................................10 1.2. Biosynthesis and structural properties of TGFβ family members............................................11 1.3. The discovery of TGFβ receptors ............................................................................................11 1.3.1. Mammalian type II serine/threonine kinases.....................................................................12 1.3.2. Mammalian type I serine/threonine kinases......................................................................12 1.3.3. Functional characteristics of the type I and II receptors....................................................14 1.4. Additional TGFβ family member binding proteins .................................................................14 1.4.1. Type III receptors..............................................................................................................14 1.4.2. Other binding proteins ......................................................................................................15 1.5. Intracellular signaling molecules .............................................................................................15 1.5.1. The Smad family...............................................................................................................15 1.5.2. Principles for Smad activation ..........................................................................................16 1.5.3. Other signaling cascades activated by TGFβ family members .........................................18 1.6. Null mice models of ser/thr kinases and Smads.......................................................................18 1.7. Ser/thr kinase receptor and Smad involvement in human disease............................................18 1.7.1. Tumorigenesis...................................................................................................................18 1.7.2. Other disorders..................................................................................................................18 2. BONE MORPHOGENETIC PROTEINS, RECEPTORS AND SMADS IN THE MAMMALIAN OVARY ..............................................................................................................................................21 2.1. General characteristics of ovarian function..............................................................................21 2.1.1. Early stages of follicular development..............................................................................21 2.1.2. Later stages of follicular development ..............................................................................21 2.1.3. The end of the follicular lifespan ......................................................................................22 2.1.4. Ovarian steroid hormone production.................................................................................23 2.2. Expression of BMPs in the mammalian ovary.........................................................................23 2.2.1. Expression of BMP receptors in the mammalian ovary....................................................24 2.2.2. Smad expression in the mammalian ovary........................................................................24 2.3. Animal models showing involvement of BMPs for ovarian function......................................25 2.4. Biological effects of recombinant BMPs in the ovary .............................................................25 3. OVARIAN INHIBINS AND THE REGULATION OF OVARIAN INHIBIN SUBUNIT EXPRESSION ....................................................................................................................................27 3.1. Historical background of inhibins ............................................................................................27 3.2. Intraovarian effects of inhibin..................................................................................................28 3.3. Inhibin receptors ......................................................................................................................28 3.4. Assays for determination of dimeric inhibins ..........................................................................28 3.5. Inhibin subunit mRNA expression in the rat ovary..................................................................29 3.5.1. Dimeric inhibin levels during the rat estrus cycle .............................................................29 3.6. Inhibin subunit expression in the human and primate ovaries .................................................29 3.6.1. Dimeric inhibin levels during the human menstrual cycle ................................................30 3.7. In vitro regulation of inhibin subunit expression .....................................................................30 AIMS OF THE STUDY........................................................................................................................32 -Local Regulators of Inhibin Production in Ovarian Granulosa Cells 5 MATERIALS AND METHODS .........................................................................................................33 1. Human granulosa-luteal cells......................................................................................................33 2. Rat granulosa cells ......................................................................................................................33 3. MIN6 cells ..................................................................................................................................33 4. 293T cells....................................................................................................................................33 5. In vitro treatment of cells ............................................................................................................34 6. Recombinant adenoviruses .........................................................................................................34 7. Transfection of rat granulosa cells ..............................................................................................34 8. RNA extraction and preparation of filters...................................................................................34 9. Preparation of cDNA probes and hybridizations ........................................................................35 10. Western blotting........................................................................................................................35 11. Protein content ..........................................................................................................................35 12. Enzyme-linked immunosorbent assay (ELISA)........................................................................35 13. Fluorescence in situ hybridization (FISH) ................................................................................36 14. ALK7 cDNA cloning ................................................................................................................36 15. Statistical methods ....................................................................................................................36 RESULTS AND DISCUSSION ...........................................................................................................37 1. CHROMOSOMAL MAPPING OF HUMAN ACTIVIN TYPE II RECEPTORS, FOLLISTATIN AND ALK7 (I AND II) ......................................................................................................................37 1.1. Activin receptor type II (ACVRII)...........................................................................................37 1.2. Activin receptor type IIB (ACVRIIB) .....................................................................................37 1.3. Follistatin (FST).......................................................................................................................38 1.4. Activin receptor-like kinase 7 (ALK7) ....................................................................................38 2. SEARCH FOR NOVEL SERINE/THREONINE KINASE RECEPTORS (II)..............................38 2.1. Cloning and characterization of ALK7 ....................................................................................38 2.2. Ovarian ALKs..........................................................................................................................39 3. EXPRESSION OF SERINE/THREONINE KINASE RECEPTORS AND SMADS IN HUMAN GRANULOSA-LUTEAL CELLS (III AND IV)................................................................................40 3.1. Ser/thr kinases..........................................................................................................................40 3.2. Smads.......................................................................................................................................41 4. STIMULATION OF INHIBIN PRODUCTION IN HUMAN GRANULOSA-LUTEAL CELLS BY BONE MORPHOGENETIC PROTEINS (III) ............................................................................41 5. OVEREXPRESSION OF ALKS AND SMADS IN HUMAN GRANULOSA-LUTEAL CELLS STIMULATES INHIBIN B PRODUCTION (IV) ...... 
1989
1989
The identification of gut diverticula at 7/8 as a synapomorphy and recognition of all taxa of Guaranidrilus has been obscured by…