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Cancer-testis gene expression profiling in esophageal squamous cell carcinoma: Identification of specific tumor marker and potential targets for immunotherapy
TLDR
Interactions between MAGE-A4, LAGE1 and NY-ESO1 and their significant clinical consequences introduce these CTAs as appropriate targets for a polyvalent cancer vaccine.
Cancer stem cell detection and isolation
TLDR
Practical and specific protocols used to isolate cancer stem cells from solid tumors from colon, esophagus, liver, breast, brain, and cervix are introduced.
High frequency of microsatellite instability in sporadic colorectal cancer patients in Iran.
TLDR
The high frequency of MSI-H in this population suggests that microsatellite instability prior to chemotherapy to determine the most appropriate chemotherapeutic strategy in the authors' population, which deserves further epidemiological attention.
Role of SALL4 in the progression and metastasis of colorectal cancer
TLDR
Along with the promising evidence of its role in self-renewal in various cancers, SALL4 may have a role in progression, development and maintenance of colorectal cancers.
Ovarian cancer stem cells and targeted therapy
TLDR
The present review summarized the recent findings about the role of CSCs in tumor relapse and drug resistance among ovarian cancer patients and focused on the targeted and combinational therapeutic methods against the ovarian C SCs.
Role of hMLH1 and E-Cadherin Promoter Methylation in Gastric Cancer Progression
TLDR
The results of this study indicate that DNA repair system is adversely affected byHypermethylation of hMLH1 in a fraction of gastric cancer patients and E-cadherin hypermethylation seen in a subset of gastrics cancer patients is consistent with other reports showing correlation with aggressiveness and metastasis.
Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review
TLDR
It is suggested that bone loss is more prevalent in celiac disease and can be associated with increased risk of fracture, however, results are pooled prevalence and the authors need more case –control studies with more sample size and consideration of confounding factors.
Correlation of Wnt and NOTCH pathways in esophageal squamous cell carcinoma
TLDR
There was a significant correlation and feedback between these markers during the ESCC progression and metastasis and cross talk between Wnt and NOTCH signaling pathways through assessment of probable correlation.
Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis
TLDR
The results documented the important role of HIWI and DPPA2 in tumorigenesis and also in lymph node metastasis of tumor cells.
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