Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3)

@article{Su2005PotentialMM,
  title={Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3)},
  author={Zao-zhong Su and Luni Emdad and Devanand Sarkar and Aaron Michael Randolph and Kristofer Valerie and A. W. Yacoub and Paul Washington Dent and Paul B Fisher},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={2247-2255}
}
Progression Elevated Gene-3 (PEG-3) was cloned using subtraction hybridization as an upregulated transcript associated with transformation and tumor progression of rat embryo fibroblast cells. PEG-3 is a unique gene facilitating tumor progression by modulating multiple pathways in transformed cells, including genomic stability, angiogenesis and invasion. PEG-3 originates from mutation in the growth arrest and DNA damage inducible gene GADD34. A one base deletion in rat GADD34 results in a frame… CONTINUE READING
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