PPP1R13L wt Allele

Known as: NKIP1, Inhibitor of Apoptosis Stimulating Protein of P53 Gene, IASPP 
Human PPP1R13L wild-type allele is located in the vicinity of 19q13.32 and is approximately 27 kb in length. This allele, which encodes RelA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2017
0102019672017

Papers overview

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2013
2013
Nearly 90% of human melanomas contain inactivated wild-type p53, the underlying mechanisms for which are not fully understood… (More)
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2011
2011
iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor… (More)
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2010
2010
iASPP is an evolutionally conserved inhibitory member of the ASPP (apoptosis-stimulating protein of p53) protein family… (More)
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2008
2008
ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53. Binding assays showed… (More)
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Highly Cited
2007
Highly Cited
2007
The tumor-suppressor function of p53 relies on its transcriptional activity, which is modulated by post-translational… (More)
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2007
2007
BACKGROUND Genetic polymorphisms involved in DNA repair and apoptosis are suspected to influence patient response to cancer… (More)
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Highly Cited
2006
Highly Cited
2006
iASPP is one of the most evolutionarily conserved inhibitors of p53, whereas ASPP1 and ASPP2 are activators of p53. We show here… (More)
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2005
2005
Inhibitory member of the ASPP family (iASPP) is an evolutionarily conserved inhibitor of p53, and its expression is upregulated… (More)
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2004
2004
ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the… (More)
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Highly Cited
2003
Highly Cited
2003
We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated… (More)
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