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PPP1R13L wt Allele

Known as: NKIP1, Inhibitor of Apoptosis Stimulating Protein of P53 Gene, IASPP 
Human PPP1R13L wild-type allele is located in the vicinity of 19q13.32 and is approximately 27 kb in length. This allele, which encodes RelA… 
National Institutes of Health

Related topics

Related topics

4 relations
19q13.32ApoptosisTranscriptional Repression

Broader (1)

PPP1R13L gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
Highly Cited
2013
Highly Cited
2013
MicroRNA-124–Mediated Regulation of Inhibitory Member of Apoptosis-Stimulating Protein of p53 Family in Experimental Stroke
Background and Purpose— p53-mediated neuronal death is a central pathway of stroke pathophysiology, but its mechanistic details… 
Highly Cited
2011
Highly Cited
2011
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor… 
2009
2009
Insight into the Structural Basis of Pro- and Antiapoptotic p53 Modulation by ASPP Proteins
p53-dependent apoptosis is modulated by the ASPP family of proteins (apoptosis-stimulating proteins of p53; also called ankyrin… 
Review
2007
Review
2007
ASPP: a new family of oncogenes and tumour suppressor genes
The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and iASPP. They bind to proteins… 
Highly Cited
2007
Highly Cited
2007
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
The tumor-suppressor function of p53 relies on its transcriptional activity, which is modulated by post-translational… 
Highly Cited
2007
Highly Cited
2007
Genetic polymorphisms and treatment response in advanced non-small cell lung cancer.
Highly Cited
2006
Highly Cited
2006
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53
iASPP is one of the most evolutionarily conserved inhibitors of p53, whereas ASPP1 and ASPP2 are activators of p53. We show here… 
Highly Cited
2005
Highly Cited
2005
The expression of iASPP in acute leukemias.
Highly Cited
2003
Highly Cited
2003
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated… 
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