POU5F1 gene

Known as: OCTAMER-BINDING TRANSCRIPTION FACTOR 4, POU Domain, Class 5, Transcription Factor 1 Gene, POU class 5 homeobox 1 
This gene plays a role in early mammalian development.
National Institutes of Health

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12 relations
Cell Differentiation processEWSR1/POU5F1 Fusion GeneHomo sapiensMorphogenesis
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POU5F1 wt Allele

Papers overview

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Highly Cited
2013
Highly Cited
2013
Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition
After fertilization, maternal factors direct development and trigger zygotic genome activation (ZGA) at the maternal-to-zygotic… (More)
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Highly Cited
2009
Highly Cited
2009
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
Realizing the full potential of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) requires efficient… (More)
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Highly Cited
2007
Highly Cited
2007
Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation…
Target genes of a transcription factor (TF) Pou5f1 (Oct3/4 or Oct4), which is essential for pluripotency maintenance and self… (More)
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Highly Cited
2006
Highly Cited
2006
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1
Embryonic stem (ES) cells are pluripotent cells that can self-renew or differentiate into many cell types. A unique network of… (More)
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Highly Cited
2006
Highly Cited
2006
POU5F1 isoforms show different expression patterns in human embryonic stem cells and preimplantation embryos.
The contribution of the POU domain, class 5, transcription factor-1 (POU5F1) in maintaining totipotency in human embryonic stem… (More)
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Highly Cited
2006
Highly Cited
2006
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-renewal of embryonic stem (ES) cells… (More)
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Highly Cited
2005
Highly Cited
2005
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.
Embryonic stem cells (ESCs) are pluripotent cells that can either self-renew or differentiate into many cell types. Oct4 and Sox2… (More)
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Highly Cited
2005
Highly Cited
2005
Transcriptional regulation of nanog by OCT4 and SOX2.
Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype… (More)
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Highly Cited
2003
Highly Cited
2003
POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors.
Human germ cell tumors (GCTs) may have variable histology and clinical behavior, depending on factors such as sex of the patient… (More)
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Highly Cited
1998
Highly Cited
1998
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
Oct4 is a mammalian POU transcription factor expressed by early embryo cells and germ cells. We report that the activity of Oct4… (More)
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