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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
The results indicate that IL-10 has important regulatory effects on immunological and inflammatory responses because of its capacity to downregulate class II MHC expression and to inhibit the production of proinflammatory cytokines by monocytes. Expand
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells
It is proposed that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells. Expand
Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses
It is demonstrated that ICAM-3 expressed by resting T cells is important in this first contact with dendritic cells, and it is predicted that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone. Expand
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major
It is indicated that IL-10 and v-IL-10 can completely prevent antigen-specific T cell proliferation by inhibition of the antigen-presenting capacity of monocytes through downregulation of class II MHC antigens on monocytes. Expand
Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force
The physical limits of cell migration in dense porous environments are dependent upon the available space and the deformability of the nucleus and are modulated by matrix metalloproteinases,Expand
Different Faces of the Heme-Heme Oxygenase System in Inflammation
Pre-induction of HO activity has been demonstrated to ameliorate inflammation and mediate potent resistance to oxidative injury and a better understanding of the complex heme-heme. Expand
DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking
It is shown that DC-SIGN, a DC-specific C-type lectin, supports tethering and rolling of DC-sign–positive cells on the vascular ligand ICAM-2 under shear flow, a prerequisite for emigration from blood. Expand
Dendritic cell immunotherapy: mapping the way
Although early clinical trials indicate that DC vaccines can induce immune responses in some cancer patients, careful study design and use of standardized clinical and immunological criteria are needed. Expand
The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells1
It is demonstrated that on DCs DC-SIGN is rapidly internalized upon binding of soluble ligand, which points to a novel function of the adhesion receptor DC- SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity. Expand
A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells
The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC- cK1 has an important rule in the induction of immune responses. Expand