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Epigenetic reprogramming in mouse primordial germ cells
Blimp1 is a critical determinant of the germ cell lineage in mice
It is shown that Blimp1 (also known as Prdm1), a known transcriptional repressor, has a critical role in the foundation of the mouse germ cell lineage, as its disruption causes a block early in the process of primordial germ cell formation.
A molecular programme for the specification of germ cell fate in mice
It is shown that fragilis, an interferon-inducible transmembrane protein, marks the onset of germ cell competence, and it is proposed that through homotypic association, it demarcates germ cells from somatic neighbours.
mRNA-Seq whole-transcriptome analysis of a single cell
A single-cell digital gene expression profiling assay with only a single mouse blastomere is described, which detected the expression of 75% more genes than microarray techniques and identified 1,753 previously unknown splice junctions called by at least 5 reads.
SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
The results reveal a role for endogenous siRNAs in mammalian oocytes and show that organisms lacking RdRP activity can produce functional endogenous si RNAs from naturally occurring dsRNAs.
Eomesodermin is required for mouse trophoblast development and mesoderm formation
The results indicate that Eomesodermin defines a conserved molecular pathway controlling the morphogenetic movements of germ layer formation and has acquired a new function in mammals in the differentiation of trophoblast.
Chromatin dynamics during epigenetic reprogramming in the mouse germ line
It is suggested that the mechanism of histone replacement is critical for these chromatin rearrangements to occur, and the marked chromatin changes are intimately linked with genome-wide DNA demethylation.
Maternal microRNAs are essential for mouse zygotic development.
The effects of the loss of maternal inheritance of miRNAs following specific deletion of Dicer from growing oocytes are shown, which demonstrates that the maternal mi RNAs are essential for the earliest stages of mouse embryonic development.