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Blimp1 is a critical determinant of the germ cell lineage in mice
Germ cell fate in mice is induced in pluripotent epiblast cells in response to signals from extraembryonic tissues. The specification of approximately 40 founder primordial germ cells and theirExpand
Epigenetic reprogramming in mouse primordial germ cells
Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early embryos, plays a crucial role in regulating genome functions at critical stages of development. We show here that mouseExpand
A molecular programme for the specification of germ cell fate in mice
Germ cell fate in mice is induced in proximal epiblast cells by the extra-embryonic ectoderm, and is not acquired through the inheritance of any preformed germ plasm. To determine precisely how germExpand
mRNA-Seq whole-transcriptome analysis of a single cell
Next-generation sequencing technology is a powerful tool for transcriptome analysis. However, under certain conditions, only a small amount of material is available, which requires more sensitiveExpand
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
RNA interference (RNAi) is a mechanism by which double-stranded RNAs (dsRNAs) suppress specific transcripts in a sequence-dependent manner. dsRNAs are processed by Dicer to 21–24-nucleotide smallExpand
SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate
Summary Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state. However, without a tractable experimental model, the mechanism of human PGC (hPGC) specificationExpand
Eomesodermin is required for mouse trophoblast development and mesoderm formation
The earliest cell fate decision in the mammalian embryo separates the extra-embryonic trophoblast lineage, which forms the fetal portion of the placenta, from the embryonic cell lineages. The bodyExpand
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states.
Embryonic stem cells (ESCs) are apparently homogeneous self-renewing cells, but we observed heterogeneous expression of Stella in ESCs, which is a marker of pluripotency and germ cells. Here we showExpand
Chromatin dynamics during epigenetic reprogramming in the mouse germ line
A unique feature of the germ cell lineage is the generation of totipotency. A critical event in this context is DNA demethylation and the erasure of parental imprints in mouse primordial germ cellsExpand
Maternal microRNAs are essential for mouse zygotic development.
MicroRNAs (miRNAs) have important roles in diverse cellular processes, but little is known about their identity and functions during early mammalian development. Here, we show the effects of the lossExpand