Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells

@article{Borrull2012NanogAO,
  title={Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells},
  author={Aur{\'e}lie Borrull and St{\'e}phanie Ghislin and Fr{\'e}d{\'e}rique Deshayes and Jessica Lauriol and Catherine Alcaide-Loridan and Sandrine Middendorp},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2012},
  volume={138},
  pages={1145-1154}
}
Melanoma tumors are highly heterogeneous and can undergo phenotypic modifications depending on their plasticity and the microenvironment, with shifts between proliferative and invasive states. We have shown that melanoma cells, grown as spheroids in a neural crest cell medium, polarize toward an invasive and motile phenotype, in agreement with transcriptomic modulations, including the up-regulation of Nanog and Oct4. Overexpression of these genes was shown to be associated with poor prognosis… CONTINUE READING
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