Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells

@article{Borrull2012NanogAO,
  title={Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells},
  author={Aur{\'e}lie Borrull and S. Ghislin and F. Deshayes and Jessica Lauriol and C. Alcaide-Loridan and S. Middendorp},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2012},
  volume={138},
  pages={1145-1154}
}
  • Aurélie Borrull, S. Ghislin, +3 authors S. Middendorp
  • Published 2012
  • Medicine, Biology
  • Journal of Cancer Research and Clinical Oncology
  • PurposeMelanoma tumors are highly heterogeneous and can undergo phenotypic modifications depending on their plasticity and the microenvironment, with shifts between proliferative and invasive states. We have shown that melanoma cells, grown as spheroids in a neural crest cell medium, polarize toward an invasive and motile phenotype, in agreement with transcriptomic modulations, including the up-regulation of Nanog and Oct4. Overexpression of these genes was shown to be associated with poor… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 47 REFERENCES
    Genomic analysis of metastasis reveals an essential role for RhoC
    • 1,439
    • Highly Influential
    • PDF
    Mechanisms of Motility in Metastasizing Cells
    • 385
    • PDF
    In vivo switching of human melanoma cells between proliferative and invasive states.
    • 467
    • Highly Influential
    • PDF
    Compensation mechanism in tumor cell migration
    • 1,242
    • Highly Influential
    • PDF
    DOCK10-Mediated Cdc42 Activation Is Necessary for Amoeboid Invasion of Melanoma Cells
    • 172
    • Highly Influential