POU5F1 wt Allele

Known as: POU Domain, Class 5, Transcription Factor 1 wt Allele, OCT4, OTF4 
Human POU5F1 wild-type allele is located in the vicinity of 6p21.31and is approximately 6 kb in length. This allele, which encodes POU domain, class… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene… (More)
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Highly Cited
2010
Highly Cited
2010
Epithelial-mesenchymal transition (EMT), a critical process of cancer invasion and metastasis, is associated with stemness… (More)
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Highly Cited
2010
Highly Cited
2010
Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity. Whereas the genomic… (More)
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Highly Cited
2010
Highly Cited
2010
Lin28 and Oct4 are highly expressed in human embryonic stem (ES) cells and, along with two other stem cell marker proteins (Nanog… (More)
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Highly Cited
2010
Highly Cited
2010
Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the introduction of Oct4, Sox2, Klf4, and c-Myc… (More)
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Review
2007
Review
2007
Several extrinsic signals such as LIF, BMP and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells… (More)
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Highly Cited
2005
Highly Cited
2005
The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of… (More)
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Highly Cited
2004
Highly Cited
2004
The Oct3/4 gene, a POU family transcription factor, has been noted as being specifically expressed in embryonic stem cells and in… (More)
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Highly Cited
2004
Highly Cited
2004
Previous studies have shown that Oct4 has an essential role in maintaining pluripotency of cells of the inner cell mass (ICM) and… (More)
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Highly Cited
2002
Highly Cited
2002
Somatic cell clones often fail at a developmental stage coincident with commencement of differentiation. The transcription factor… (More)
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