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PLK1 gene

Known as: PLK1, PLK, SERINE/THREONINE PROTEIN KINASE 13 
This gene plays a role in mitotic regulation.
National Institutes of Health

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Related topics

8 relations
CytokinesisMitosisPLK1 protein, humanPhosphorylation

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PLK1 wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification
Summary Centrosome duplication is licensed by the disengagement, or ‘uncoupling’, of centrioles during late mitosis. However… 
Review
2009
Review
2009
Discovery and development of aurora kinase inhibitors as anticancer agents.
The process of cell division or mitosis is highly complex and tightly regulated. During this phase of the cell cycle two… 
Highly Cited
2009
Highly Cited
2009
Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.
Abnormal centrosome and centriole numbers are frequently detected in tumor cells where they can contribute to mitotic aberrations… 
2008
2008
Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression
Polo-like kinase 1 (Plk1), the best characterized member of the mammalian polo-like kinase family, is well regulated throughout… 
2008
2008
Downregulation of Plk1 expression by receptor-mediated uptake of antisense oligonucleotide-loaded nanoparticles.
Human serum albumin (HSA) nanoparticles represent a promising tool for targeted drug delivery to tumor cells. The coupling of the… 
Highly Cited
2006
Highly Cited
2006
Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
Highly Cited
2004
Highly Cited
2004
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of…
Hepatoblastoma is one of the most common malignant liver tumors in young children. Recent evidences have suggested that the… 
Highly Cited
2001
Highly Cited
2001
The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes.
In the Xenopus oocyte system mitogen treatment triggers the G(2)/M transition by transiently inhibiting the cAMP-dependent… 
Highly Cited
2001
Highly Cited
2001
Polo-like kinase interacts with proteasomes and regulates their activity.
The polo-like kinase (Plk) has been shown to be associated with the anaphase-promoting complex at the transition from metaphase… 
Highly Cited
1999
Highly Cited
1999
Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex.
The polo-like kinase (Plk) family has been shown to have an important role in the regulation of the cell-division cycle… 
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