PLK1 wt Allele

Known as: Polo (Drosophia)-Like Kinase Gene, PLK, Polo-Like Kinase 1 (Drosophila) Gene 
Human PLK1 wild-type allele is located in the vicinity of 16p12.1 and is approximately 11 kb in length. This allele, which encodes serine/threonine… (More)
National Institutes of Health

Papers overview

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Review
2011
Review
2011
The Polo-like kinases (PLKs) have been investigated as oncology targets for several years; however, only recently have potent… (More)
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Review
2005
Review
2005
Polo-like kinases (PLKs) are key enzymes that control mitotic entry of proliferating cells and regulate many aspects of mitosis… (More)
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Highly Cited
2004
Highly Cited
2004
By using a genome-wide approach, we sought the identification of p53-regulated genes involved in cellular apoptosis. To this end… (More)
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Highly Cited
2002
Highly Cited
2002
No clear patterns in molecular changes underlying the malignant processes in lung cancer of different histological types have… (More)
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Highly Cited
2001
Highly Cited
2001
Background: Disruption of normal mechanisms for cell cycle regulation is important in carcinogenesis. SAK and PLK are members of… (More)
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Highly Cited
2000
Highly Cited
2000
Entry into mitosis by mammalian cells is triggered by the activation of the cdc2/cyclin B holoenzyme. This is accomplished by the… (More)
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Highly Cited
1999
Highly Cited
1999
Previously, we demonstrated that the mammalian polo-like kinase (PLK), which participates in the regulation of the cell cycle, is… (More)
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1999
1999
PLK (polo-like kinase), which belongs to a family of serine/threonine kinases and represents the human counterpart of… (More)
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Highly Cited
1997
Highly Cited
1997
PLK (polo-like kinase) belongs to a family of serine/threonine kinases and represents the human counterpart of polo in Drosophila… (More)
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Highly Cited
1994
Highly Cited
1994
We have identified the nucleotide sequence of the cDNA encoding the human counterpart of the mouse gene Plk (polo-like kinase… (More)
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