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The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.
BACKGROUND The survival of patients with diffuse large-B-cell lymphoma after chemotherapy is influenced by molecular features of the tumors. We used the gene-expression profiles of these lymphomas toExpand
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Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We present a set of integratedExpand
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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used asExpand
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Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colonExpand
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Complete molecular remissions induced by patient-specific vaccination plus granulocyte–monocyte colony-stimulating factor against lymphoma
Lymphomas express a tumor-specific antigen which can be targeted by cancer vaccination. We evaluated the ability of a new idiotype protein vaccine formulation to eradicate residual t(14;18)+ lymphomaExpand
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Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.
Murine bone marrow cells expressing the cell surface Ag RB6-8C5 were identified by fluorescence-activated cell-sorting analysis using a rat IgG mAb. The fluorescent intensity of RB6-8C5 was variableExpand
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Interleukin-6 in aging and chronic disease: a magnificent pathway.
The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article "IL-6: A Cytokine for Gerontologists," indicated IL-6 as one of the main signaling pathwaysExpand
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Red blood cell distribution width and the risk of death in middle-aged and older adults.
BACKGROUND Red blood cell distribution width (RDW), a component of an electronic complete blood count, is a measure of heterogeneity in the size of circulating erythrocytes. In patients withExpand
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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but because only a percentage of patients are responsive to immunotherapy, it is imperative to identify factorsExpand
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Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
To examine transcription factor (TF) network(s), we created mouse ESC lines, in each of which 1 of 50 TFs tagged with a FLAG moiety is inserted into a ubiquitously controllableExpand
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