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The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.
- A. Rosenwald, George W. Wright, +37 authors L. Staudt
- The New England journal of medicine
- 20 June 2002
BACKGROUND The survival of patients with diffuse large-B-cell lymphoma after chemotherapy is influenced by molecular features of the tumors. We used the gene-expression profiles of these lymphomas to… Expand
Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We present a set of integrated… Expand
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as… Expand
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
- H. Mizoguchi, J. O'Shea, D. Longo, C. Loeffler, D. McVicar, A. Ochoa
- Biology, Medicine
- 11 December 1992
Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colon… Expand
Complete molecular remissions induced by patient-specific vaccination plus granulocyte–monocyte colony-stimulating factor against lymphoma
Lymphomas express a tumor-specific antigen which can be targeted by cancer vaccination. We evaluated the ability of a new idiotype protein vaccine formulation to eradicate residual t(14;18)+ lymphoma… Expand
Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.
Murine bone marrow cells expressing the cell surface Ag RB6-8C5 were identified by fluorescence-activated cell-sorting analysis using a rat IgG mAb. The fluorescent intensity of RB6-8C5 was variable… Expand
Interleukin-6 in aging and chronic disease: a magnificent pathway.
- M. Maggio, J. Guralnik, D. Longo, L. Ferrucci
- The journals of gerontology. Series A, Biological…
- 1 June 2006
The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article "IL-6: A Cytokine for Gerontologists," indicated IL-6 as one of the main signaling pathways… Expand
Red blood cell distribution width and the risk of death in middle-aged and older adults.
- K. Patel, L. Ferrucci, W. Ershler, D. Longo, J. Guralnik
- Archives of internal medicine
- 9 March 2009
BACKGROUND Red blood cell distribution width (RDW), a component of an electronic complete blood count, is a measure of heterogeneity in the size of circulating erythrocytes. In patients with… Expand
Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but because only a percentage of patients are responsive to immunotherapy, it is imperative to identify factors… Expand
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
To examine transcription factor (TF) network(s), we created mouse ESC lines, in each of which 1 of 50 TFs tagged with a FLAG moiety is inserted into a ubiquitously controllable… Expand