Skip to search formSkip to main contentSkip to account menu

PLK1 protein, human

Known as: Serine/Threonine-Protein Kinase PLK1, Serine/Threonine-Protein Kinase 13, Polo-Like Kinase 
Serine/threonine-protein kinase PLK1 (603 aa, ~68 kDa) is encoded by the human PLK1 gene. This protein is involved in protein phosphorylation and the… 
National Institutes of Health

Related topics

Related topics

16 relations
Cell CycleCytokinesisEnzyme GeneGSK 461364

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC.
Cytokinesis is the critical final step in cell division. BRCA2 disruption during cytokinesis is associated with chromosome… 
2013
2013
An analogue-sensitive approach identifies basal body rotation and flagellum attachment zone elongation as key functions of PLK in Trypanosoma brucei
The Polo-like kinase homologue in Trypanosoma brucei (TbPLK) regulates the assembly of a series of organelles necessary for… 
2011
2011
Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus
AMP-activated protein kinase (AMPK) is being primarily studied as a central metabolic stress sensor, which regulates cell… 
Highly Cited
2008
Highly Cited
2008
P21-activated kinase is required for mitotic progression and regulates Plk1
P21-activated kinases (Paks), a family of serine/threonine kinases, are effectors of the Rho GTPases Cdc42 and Rac1. Mammalian… 
Highly Cited
2008
Highly Cited
2008
Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer
Liver metastasis is one of the most important prognostic factors in lung cancer patients. However, current therapies are not… 
2008
2008
Ability of CK2β to selectively regulate cellular protein kinases
The Wee1 protein kinase plays a prominent role in keeping cyclin dependent kinase 1 (CDK1) inactive during the G2 phase of the… 
Highly Cited
2007
Highly Cited
2007
Regulation of Polo-like Kinase 1 by DNA Damage in Mitosis
DNA damage triggers multiple checkpoint pathways to arrest cell cycle progression. Polo-like kinase 1 (Plk1) is an important… 
Highly Cited
2006
Highly Cited
2006
Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
Highly Cited
2003
Highly Cited
2003
Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR.
The role of the protein kinase B (PKB/Akt) in the regulation of cell survival and proliferation is well established. PKB is a key… 
Highly Cited
2002
Highly Cited
2002
Cell Cycle-regulated Phosphorylation of the XenopusPolo-like Kinase Plx1*
Polo-like kinases (Plks) control multiple important events during M phase progression, but little is known about their activation… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)