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PLCG1 gene

Known as: PHOSPHOLIPASE C-148, PLC-II, PLC1 
This gene is involved in both intracellular signaling and second messenger production.
National Institutes of Health

Related topics

Related topics

6 relations
Cytokine SignalingHydrolysisPhospholipase C gamma1Phospholipid Metabolism

Papers overview

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Highly Cited
2016
Highly Cited
2016
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas.
Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-helper cells (TFH) represent a large… 
Highly Cited
2014
Highly Cited
2014
Recurrent PTPRB and PLCG1 mutations in angiosarcoma
Angiosarcoma is an aggressive malignancy that arises spontaneously or secondarily to ionizing radiation or chronic lymphoedema… 
Review
2007
Review
2007
Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: Implications for oligodendrocyte…
Highly Cited
2005
Highly Cited
2005
Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes.
Store-operated calcium entry depicts the movement of extracellular Ca2+ into cells through plasma membrane Ca2+ channels… 
Highly Cited
2005
Highly Cited
2005
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.
Phospholipase C-gamma (PLCgamma) is a key regulator of intracellular Ca(2+) mobilization. Two isoforms of PLCgamma have been… 
Highly Cited
2002
Highly Cited
2002
Absence of Erythrogenesis and Vasculogenesis in Plcg1-deficient Mice*
Mice nullizygous for Plcg1 cease growing at early to mid-gestation. An examination of carefully preserved wild-type embryos shows… 
Highly Cited
2001
Highly Cited
2001
Sperm Factor Induces Intracellular Free Calcium Oscillations by Stimulating the Phosphoinositide Pathway1
Abstract Injection of a porcine cytosolic sperm factor (SF) or of a porcine testicular extract into mammalian eggs triggers… 
Highly Cited
1998
Highly Cited
1998
INP51, a Yeast Inositol Polyphosphate 5-Phosphatase Required for Phosphatidylinositol 4,5-Bisphosphate Homeostasis and Whose Absence Confers a Cold-resistant Phenotype*
Sequence analysis of Saccharomyces cerevisiae chromosome IX identified a 946 amino acid open reading frame (YIL002C), designated… 
Highly Cited
1993
Highly Cited
1993
The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growth.
Using the polymerase chain reaction technique, we have isolated a gene that encodes a putative phosphoinositide-specific… 
Highly Cited
1993
Highly Cited
1993
A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation
We identified a putative Saccharomyces cerevisiae homolog of a phosphoinositide-specific phospholipase C (PI-PLC) gene, PLC1… 
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