• Publications
  • Influence
Vitamin D metabolism, mechanism of action, and clinical applications.
  • D. Bikle
  • Medicine, Biology
  • Chemistry & biology
  • 20 March 2014
Vitamin D3 is made in the skin from 7-dehydrocholesterol under the influence of UV light. Vitamin D2 (ergocalciferol) is derived from the plant sterol ergosterol. Vitamin D is metabolized first to 25Expand
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Nonclassic actions of vitamin D.
  • D. Bikle
  • Medicine
  • The Journal of clinical endocrinology and…
  • 2009
CONTEXT Vitamin D receptors are found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney. These nonclassic tissues are therefore potentialExpand
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Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
An essential element of the innate immune response to injury is the capacity to recognize microbial invasion and stimulate production of antimicrobial peptides. We investigated how this process isExpand
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The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.
Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is expressed inExpand
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The Extracellular Calcium-Sensing Receptor (CaSR) Is a Critical Modulator of Skeletal Development
The extracellular calcium-sensing receptor (CaSR) is essential for embryonic and postnatal skeletal development. Bone Censor The extracellular calcium-sensing receptor (CaSR) is a guanineExpand
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Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein.
We measured the free fraction of 25-hydroxyvitamin D (25OHD) in human serum and determined that 25OHD bound to a component with an affinity constant of 7 X 10(8) M-1 and a concentration of 4.5 XExpand
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A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations.
OBJECTIVE Our goal was to compare direct quantitation of circulating free 25-hydroxyvitamin D (25(OH)D)levels to calculated free 25(OH)D levels and their relationships to intact PTH (iPTH), aExpand
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Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels.
Using the technique of centrifugal ultrafiltration isodialysis to measure the free concentration of 1,25-dihydroxyvitamin D [1,25-(OH)2D], we determined the affinity of serum proteins for 1,25-(OH)2DExpand
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Insulin‐Like Growth Factor I Is Required for the Anabolic Actions of Parathyroid Hormone on Mouse Bone
Parathyroid hormone (PTH) is a potent anabolic agent for bone, but the mechanism(s) by which it works remains imperfectly understood. Previous studies have indicated that PTH stimulates insulin‐likeExpand
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PTH Differentially Regulates Expression of RANKL and OPG
RANKL and OPG gene expressions were measured with and without PTH at different stages of osteoblast development. Mouse stromal cells were cultured in osteoblast differentiating conditions, and RANKL,Expand
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