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PLA2G4C protein, human

Known as: Phospholipase A2IVC, Cytosolic Phospholipase A2 Gamma, PLA2G4C 
Cytosolic phospholipase A2 gamma (541 aa, ~61 kDa) is encoded by the human PLA2G4C gene. This protein is involved in phospholipid hydrolysis.
National Institutes of Health

Related topics

Related topics

14 relations
C2 DomainsEnzyme GeneEsterase GeneHydrolase

Broader (2)

Cytosolic Phospholipase A2Phospholipases A2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The Tissue-Engineered Human Psoriatic Skin Substitute: A Valuable In Vitro Model to Identify Genes with Altered Expression in Lesional Psoriasis
Psoriasis is a chronic inflammatory skin disease for which no cure has emerged. Its complex etiology requires the development of… 
2017
2017
Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation.
2015
2015
Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy.
X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene… 
Highly Cited
2012
Highly Cited
2012
Cytosolic Phospholipase A2 Gamma Is Involved in Hepatitis C Virus Replication and Assembly
ABSTRACT Similar to other positive-sense, single-stranded RNA viruses, hepatitis C virus (HCV) replicates its genome in a… 
2012
2012
Combined metabonomic and quantitative real-time PCR analyses reveal systems metabolic changes in Jurkat T-cells treated with HIV-1 Tat protein.
HIV-1 Tat protein is released by infected cells and can affect bystander uninfected T cells and induce numerous biological… 
2010
2010
Modulation of the activity of cytosolic phospholipase A2α (cPLA2α) by cellular sphingolipids and inhibition of cPLA2α by sphingomyelin[S]
We examined the effect of the cellular sphingolipid level on the release of arachidonic acid (AA) and activity of cytosolic… 
2010
2010
Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth
BackgroundThe onset of birth in humans, like other apes, differs from non-primate mammals in its endocrine physiology. We… 
2007
2007
Implication of cytosolic phospholipase A2 (cPLA2) in the regulation of human synoviocyte NADPH oxidase (Nox2) activity.
Highly Cited
2001
Highly Cited
2001
Cytosolic Phospholipase A2 Participates with TNF-α in the Induction of Apoptosis of Human Macrophages Infected with Mycobacterium tuberculosis H37Ra1
Macrophage (MΦ) apoptosis, an important innate microbial defense mechanism induced by Mycobacterium tuberculosis (Mtb) H37Ra… 
Highly Cited
1999
Highly Cited
1999
Molecular Characterization of Cytosolic Phospholipase A2-β*
We have isolated a cDNA encoding a 1012-amino acid polypeptide cPLA2-β, that has significant homology with cPLA2-α in both the… 
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