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PGGT1B wt Allele

Known as: BGGI, GGTI, Protein Geranylgeranyltransferase Type I, Beta Subunit wt Allele 
Human PGGT1B wild-type allele is located in the vicinity of 5q22.3 and is approximately 51 kb in length. This allele, which encodes geranylgeranyl… Expand
National Institutes of Health

Papers overview

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2016
2016
Stroke is the fifth leading cause of death for Americans, and about 87% of all strokes are ischemic strokes. Astrogliosis plays a… Expand
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2012
2012
Thesis (Ph.D.) -- University of Adelaide, School of Population Health and Clinical Practice and School of Paediatrics and… Expand
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Highly Cited
2012
Highly Cited
2012
Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that… Expand
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2012
2012
Protein farnesyltransferase (FTase) inhibitors, generally called "FTIs," block the farnesylation of prelamin A, inhibiting the… Expand
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2009
2009
We describe the design of a potent and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI-2418, and… Expand
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2008
2008
Protein geranylgeranylation is critical for the function of a number of proteins such as RhoA, Rac, and Rab. Protein… Expand
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2005
2005
The high incidence of activating RAS mutations, coupled with accumulating evidence linking RAS to multiple myeloma (MM… Expand
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2002
2002
Here we demonstrate that the geranylgeranyltransferase-I inhibitor GGTI-298 inhibits the RhoB pathway and disrupts stress fiber… Expand
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Highly Cited
2001
Highly Cited
2001
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the… Expand
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2001
2001
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the… Expand
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