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PGGT1B wt Allele
Known as:
BGGI
, GGTI
, Protein Geranylgeranyltransferase Type I, Beta Subunit wt Allele
Human PGGT1B wild-type allele is located in the vicinity of 5q22.3 and is approximately 51 kb in length. This allele, which encodes geranylgeranyl…
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National Institutes of Health
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Related topics
Related topics
6 relations
5q22.3
Isoprenylation
PGGT1B protein, human
Post-Translational Protein Processing
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Broader (1)
PGGT1B gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia
Shangfeng Gao
,
Jianbing Mo
,
+6 authors
Xiuping Zhou
Neuropharmacology
2016
Corpus ID: 27430793
2012
2012
Intrauterine influences on obesity and insulin resistance in pre-pubertal children.
O. Maftei
2012
Corpus ID: 79139999
Thesis (Ph.D.) -- University of Adelaide, School of Population Health and Clinical Practice and School of Paediatrics and…
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Highly Cited
2012
Highly Cited
2012
Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
Avik Roy
,
A. Ghosh
,
+4 authors
K. Pahan
PLoS ONE
2012
Corpus ID: 3239264
Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that…
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2010
2010
Melanoma Cells Treated with GGTI and IFN-γ Allow Murine Vaccination and Enhance Cytotoxic Response against Human Melanoma Cells
G. Sarrabayrouse
,
C. Pich
,
+4 authors
A. Tilkin-Mariamé
PLoS ONE
2010
Corpus ID: 13447787
Background Suboptimal activation of T lymphocytes by melanoma cells is often due to the defective expression of class I major…
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Highly Cited
2009
Highly Cited
2009
Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy
Aslamuzzaman Kazi
,
A. Carie
,
+10 authors
S. Sebti
Molecular and Cellular Biology
2009
Corpus ID: 206827087
ABSTRACT We describe the design of a potent and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI…
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Highly Cited
2008
Highly Cited
2008
Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds*
Masaru Watanabe
,
Hannah D. G. Fiji
,
+5 authors
F. Tamanoi
Journal of Biological Chemistry
2008
Corpus ID: 29233233
Protein geranylgeranylation is critical for the function of a number of proteins such as RhoA, Rac, and Rab. Protein…
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2005
2005
Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS‐to‐MAP kinase signalling in multiple myeloma cells
M. Morgan
,
Tarkan Sebil
,
E. Aydilek
,
D. Peest
,
A. Ganser
,
C. Reuter
British Journal of Haematology
2005
Corpus ID: 21478334
The high incidence of activating RAS mutations, coupled with accumulating evidence linking RAS to multiple myeloma (MM…
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2002
2002
Farnesylated RhoB Prevents Cell Cycle Arrest and Actin Cytoskeleton Disruption Caused by the Geranylgeranyltransferase I Inhibitor GGTI-298
C. Allal
,
A. Pradines
,
A. Hamilton
,
S. Sebti
,
G. Favre
Cell Cycle
2002
Corpus ID: 27225762
Here we demonstrate that the geranylgeranyltransferase-I inhibitor GGTI-298 inhibits the RhoB pathway and disrupts stress fiber…
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Highly Cited
2001
Highly Cited
2001
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
R. Lobell
,
C. Omer
,
+18 authors
N. Kohl
Cancer Research
2001
Corpus ID: 16683279
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the…
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2001
2001
Preclinical Models Geranylgeranyl : Protein Transferase Inhibitor Combinations in Evaluation of Farnesyl : Protein Transferase and Updated
R. Lobell
,
C. Omer
,
+18 authors
N. Kohl
2001
Corpus ID: 17652439
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the…
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