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PGGT1B wt Allele

Known as: BGGI, GGTI, Protein Geranylgeranyltransferase Type I, Beta Subunit wt Allele 
Human PGGT1B wild-type allele is located in the vicinity of 5q22.3 and is approximately 51 kb in length. This allele, which encodes geranylgeranyl… 
National Institutes of Health

Related topics

Related topics

6 relations
5q22.3IsoprenylationPGGT1B protein, humanPost-Translational Protein Processing

Broader (1)

PGGT1B gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain
Isoprenylation is a posttranslational modification that transfers farnesyl pyrophosphate (FPP) or geranylgeranyl pyrophosphate… 
2013
2013
Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion
Glioblastoma multiforme is a highly migratory and invasive brain tumor in which hypoxia inducible factor-1α (HIF-1α) plays… 
2012
2012
Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24
Protein farnesyltransferase (FTase) inhibitors, generally called “FTIs,” block the farnesylation of prelamin A, inhibiting the… 
2011
2011
Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells
PurposeGeranylgeranyltransferase I is required for the prenylation of the small GTPases. The effect of GGTase I inhibitors (GGTIs… 
Highly Cited
2009
Highly Cited
2009
Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy
ABSTRACT We describe the design of a potent and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI… 
2006
2006
Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells
Progesterone receptor (PR) stimulation promotes survival in human and rat periovulatory granulosa cells. PR antagonists, Org… 
2005
2005
Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS‐to‐MAP kinase signalling in multiple myeloma cells
The high incidence of activating RAS mutations, coupled with accumulating evidence linking RAS to multiple myeloma (MM… 
2005
2005
Inhibition of geranylgeranyltransferase I decreases generation of vascular reactive oxygen species and increases vascular nitric oxide production.
2002
2002
Farnesylated RhoB Prevents Cell Cycle Arrest and Actin Cytoskeleton Disruption Caused by the Geranylgeranyltransferase I Inhibitor GGTI-298
Here we demonstrate that the geranylgeranyltransferase-I inhibitor GGTI-298 inhibits the RhoB pathway and disrupts stress fiber… 
2001
2001
Preclinical Models Geranylgeranyl : Protein Transferase Inhibitor Combinations in Evaluation of Farnesyl : Protein Transferase and Updated
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the… 
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