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PGGT1B wt Allele

Known as: BGGI, GGTI, Protein Geranylgeranyltransferase Type I, Beta Subunit wt Allele 
Human PGGT1B wild-type allele is located in the vicinity of 5q22.3 and is approximately 51 kb in length. This allele, which encodes geranylgeranyl… 
National Institutes of Health

Related topics

Related topics

6 relations
5q22.3IsoprenylationPGGT1B protein, humanPost-Translational Protein Processing

Broader (1)

PGGT1B gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia
2012
2012
Intrauterine influences on obesity and insulin resistance in pre-pubertal children.
Thesis (Ph.D.) -- University of Adelaide, School of Population Health and Clinical Practice and School of Paediatrics and… 
Highly Cited
2012
Highly Cited
2012
Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that… 
2010
2010
Melanoma Cells Treated with GGTI and IFN-γ Allow Murine Vaccination and Enhance Cytotoxic Response against Human Melanoma Cells
Background Suboptimal activation of T lymphocytes by melanoma cells is often due to the defective expression of class I major… 
Highly Cited
2009
Highly Cited
2009
Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy
ABSTRACT We describe the design of a potent and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI… 
Highly Cited
2008
Highly Cited
2008
Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds*
Protein geranylgeranylation is critical for the function of a number of proteins such as RhoA, Rac, and Rab. Protein… 
2005
2005
Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS‐to‐MAP kinase signalling in multiple myeloma cells
The high incidence of activating RAS mutations, coupled with accumulating evidence linking RAS to multiple myeloma (MM… 
2002
2002
Farnesylated RhoB Prevents Cell Cycle Arrest and Actin Cytoskeleton Disruption Caused by the Geranylgeranyltransferase I Inhibitor GGTI-298
Here we demonstrate that the geranylgeranyltransferase-I inhibitor GGTI-298 inhibits the RhoB pathway and disrupts stress fiber… 
Highly Cited
2001
Highly Cited
2001
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the… 
2001
2001
Preclinical Models Geranylgeranyl : Protein Transferase Inhibitor Combinations in Evaluation of Farnesyl : Protein Transferase and Updated
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the… 
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