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PGGT1B wt Allele

Known as: BGGI, GGTI, Protein Geranylgeranyltransferase Type I, Beta Subunit wt Allele 
Human PGGT1B wild-type allele is located in the vicinity of 5q22.3 and is approximately 51 kb in length. This allele, which encodes geranylgeranyl… 
National Institutes of Health

Papers overview

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2012
2012
Thesis (Ph.D.) -- University of Adelaide, School of Population Health and Clinical Practice and School of Paediatrics and… 
Highly Cited
2012
Highly Cited
2012
Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that… 
2012
2012
Protein farnesyltransferase (FTase) inhibitors, generally called “FTIs,” block the farnesylation of prelamin A, inhibiting the… 
Highly Cited
2009
Highly Cited
2009
ABSTRACT We describe the design of a potent and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI… 
Highly Cited
2008
Highly Cited
2008
Protein geranylgeranylation is critical for the function of a number of proteins such as RhoA, Rac, and Rab. Protein… 
2005
2005
The high incidence of activating RAS mutations, coupled with accumulating evidence linking RAS to multiple myeloma (MM… 
2002
2002
Here we demonstrate that the geranylgeranyltransferase-I inhibitor GGTI-298 inhibits the RhoB pathway and disrupts stress fiber… 
Highly Cited
2001
Highly Cited
2001
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the… 
2001
2001
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the…