Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells

@article{Hamada2010InvolvementOR,
  title={Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells},
  author={Masakazu Hamada and Tetsuei Miki and Soichi Iwai and Hidetaka Shimizu and Yoshiaki Yura},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2010},
  volume={68},
  pages={559-569}
}
Geranylgeranyltransferase I is required for the prenylation of the small GTPases. The effect of GGTase I inhibitors (GGTIs) on oral squamous cell carcinoma (SCC) cells was examined. The GGTI-treated cells were examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay, flow cytometric analysis, transwell chamber assays, and immunofluorescent staining. Small GTPases were detected by immunoblot analysis, and siRNA were used for silencing RalA and RalB. GGTI suppressed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-5 of 5 extracted citations

Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico • 2015
View 1 Excerpt

Migration and invasion of oral squamous carcinoma cells is promoted by WNT5A, a regulator of cancer progression.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Expression of ral GTPases, their effectors, and activators in human bladder cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…